Brain structure in sagittal craniosynostosis.
Brain structure in sagittal craniosynostosis.
复制标题
矢状位颅缝早闭的脑结构。
DOI：
10.1117/12.2254442
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Patel,Kamlesh
中科院分区：
文献类型：
--
作者：
Paniagua,Beatriz;Kim,Sunghyung;Moustapha,Mahmoud;Styner,Martin;Cody-Hazlett,Heather;Gimple-Smith,Rachel;Rumple,Ashley;Piven,Joseph;Gilmore,John;Skolnick,Gary;Patel,Kamlesh
颅缝早闭，一个或多个颅缝的过早融合，导致严重异常的头部形状和由这些畸形引起的脑内压力升高。迄今为止，颅缝早闭的公认治疗包括改善手术颅骨形状美学。然而，手术后改善的头型与大脑结构之间的关系尚未建立。通常，临床标准护理涉及收集诊断性医学计算机断层扫描（CT）成像，以评价融合缝线并计划手术治疗。已知CT提供颅骨中硬组织的非常好的重建，但是它不能获得良好的软脑组织对比度。本研究旨在使用磁共振成像来评估矢状面颅缝早闭患者的小数据集中的脑结构，从而量化手术干预对整体脑结构的影响。非常重要的是，这些效果将与标准形状，体积和大脑结构数据库进行对比。这里提出的工作希望解决颅缝早闭临床知识的差距，重点是了解手术后脑体积和形状的变化，并将其与正常发育的儿童进行比较。这项初步试点研究有可能为弱势患者群体的手术护理提高显着的质量，我们目前对这些患者群体的大脑发育结果了解有限。
Craniosynostosis, the premature fusion of one or more cranial sutures, leads to grossly abnormal head shapes and pressure elevations within the brain caused by these deformities. To date, accepted treatments for craniosynostosis involve improving surgical skull shape aesthetics. However, the relationship between improved head shape and brain structure after surgery has not been yet established. Typically, clinical standard care involves the collection of diagnostic medical computed tomography (CT) imaging to evaluate the fused sutures and plan the surgical treatment. CT is known to provide very good reconstructions of the hard tissues in the skull but it fails to acquire good soft brain tissue contrast. This study intends to use magnetic resonance imaging to evaluate brain structure in a small dataset of sagittal craniosynostosis patients and thus quantify the effects of surgical intervention in overall brain structure. Very importantly, these effects are to be contrasted with normative shape, volume and brain structure databases. The work presented here wants to address gaps in clinical knowledge in craniosynostosis focusing on understanding the changes in brain volume and shape secondary to surgery, and compare those with normally developing children. This initial pilot study has the potential to add significant quality to the surgical care of a vulnerable patient population in whom we currently have limited understanding of brain developmental outcomes.