Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry
Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry
复制标题
DOI：
10.1016/j.jsbmb.2011.05.009
复制
发表时间：
2011-11-01
影响因子：
4.1
通讯作者：
Parra, Esteban J.
中科院分区：
文献类型：
--
作者：
Gozdzik, Agnes;Zhu, Justin;Parra, Esteban J.
维生素D结合蛋白(VDBP)基因的变异似乎与循环中主要的维生素D代谢物25-羟基维生素D[(25(OH)D])的水平有关。我们研究了VDBP(GC)基因常见变种与25(OH)D浓度之间的关系，考虑了维生素D摄入量、皮肤色素沉着、性别、BMI、阳光暴露量和季节的影响。对351名健康青年进行了T436K(Rs4588)和D432E(Rs7041)两个非同义单核苷酸多态(SNPs)的基因分型。在控制了多个回归模型中的相关预测变量后，发现GC-2(436K)等位基因的数量与秋季和冬季访问东亚样本中较低的25(OH)D浓度有关。在欧洲样本中，GC-2等位基因的数量也与Fall 25(OH)D浓度呈显著负相关。在南亚样本中，GC-2等位基因数目与25(OH)D在任何季节均未发现关联。维生素D摄入量也显著预测血清25(OHD)浓度，与观察到的GC多态相似，这种关联的相对强度受血统和季节的影响。(C)2011爱思唯尔有限公司。保留所有权利。
Variants of the vitamin D binding protein (VDBP) gene appear to be associated with levels of the main circulating vitamin D metabolite, 25-hydroxyvitamin D [(25(OH)D]. We examined the associations between the common variants of the VDBP (GC) gene and concentrations of 25(OH)D in a sample of young Canadian adults of East Asian, European and South Asian ancestry, taking into account the effect of vitamin D intake, skin pigmentation, sex, BMI, sun exposure and season. Three hundred and fifty-one (351) healthy young adults were genotyped for two non-synonymous single nucleotide polymorphisms (SNPs),T436K (rs4588) and D432E (rs7041), using a method that ascertains the GC cliplotypes of each individual. After controlling for relevant predictor variables in multiple regression models, the number of GC-2 (436 K) alleles was found to be associated with lower 25(OH)D concentrations in the East Asian sample at fall and winter visits. The number of GC-2 alleles also showed a significant negative association with fall 25(OH)D concentration in the European sample. No associations were noted between the number of GC-2 alleles and 25(OH)D in the South Asian sample at either season. Vitamin D intake was also significantly predictive of serum 25(OHD) concentrations, and similarly to what was observed for the GC polymorphisms, the relative strength of the association was influenced by ancestry and season. (C) 2011 Elsevier Ltd. All rights reserved.