P300 as An Index of Transition to Psychosis and of Remission: Data from A Clinical High Risk for Psychosis Study and Review of Literature.
P300 as An Index of Transition to Psychosis and of Remission: Data from A Clinical High Risk for Psychosis Study and Review of Literature.
复制标题
P300 作为向精神病转变和缓解的指标：来自精神病临床高风险研究和文献综述的数据。
DOI：
10.1016/j.schres.2019.02.014
复制
发表时间：
2020
影响因子：
4.5
通讯作者：
Margaret A Niznikiewicz
中科院分区：
文献类型：
--
作者：
Yingying Tang;Junjie Wang;Tianhong Zhang;Lihua Xu;Zhenying Qian;Huiru Cui;Xiaochen Tang;Huijun Li;Susan Whitfield-Gabrieli;Martha E Shenton;Larry J Seidman;Robert W McCarley;Matcheri S Keshavan;William S Stone;Jijun Wang;Margaret A Niznikiewicz
听觉P300的古怪成分和新颖成分分别指示工作记忆操作和突显加工，并被认为是慢性和首发精神分裂症神经认知变化的生物标志物。关于P300异常是否存在于临床精神病高危人群中，以及它们是否是向精神病的转变和症状缓解的预测因子，我们知道的要少得多。104名CHR和69名健康对照(HC)完成了P300古怪范式，131名CHR和69名HC完成了P300新范式。对所有CHR受试者进行为期一年的随访，并将其分为CHR转化组(CHR单键C)和非转化组(CHR-NC)，CHR-NC进一步分为缓解组和未缓解组。比较CHR单键C、ChR-NC和HC之间以及CHR单键C与未缓解、缓解期和HC之间的P300波幅和新波幅及潜伏期的组间比较。与HC相比，CHR转换器具有较低的额中枢型P300新奇波幅和略低的P300奇怪波幅。将缓解组和未缓解组分为缓解组和未缓解组，缓解组P300新波幅与HC相当，高于转化为精神病或未缓解组。因此，P300新型幅度指标化受损的突显加工障碍标志着向精神病的转变和精神病症状的缓解。
Auditory P300 oddball and novel components index working memory operations and salience processing, respectively, and are regarded as biomarkers of neurocognitive changes in both chronic and first-episode schizophrenia. Much less is known about whether P300 abnormalities exist in individuals at clinical high risk for psychosis (CHR) and if they are predictors of both transition to psychosis and remission from symptoms. One hundred and four CHR and 69 healthy control individuals (HC) completed P300 oddball paradigm, and 131 CHR and 69 HC subjects completed P300 novel paradigm. All CHR subjects were followed up for one year and stratified into CHR converters (CHRsingle bondC) and non-converters (CHR-NC), with CHR-NC further stratified into remitted and non-remitted subgroups. Between-group comparisons of P300 oddball and novel amplitude and latency were performed among CHRsingle bondC, CHR-NC and HC, as well as among CHRsingle bondC, non-remitted CHR, remitted CHR and HC. CHR converters had lower fronto-central P300 novel amplitude as well as marginally lower P300 oddball amplitude relative to HC. When CHR non-converters were stratified into remitted and non-remitted subgroups, P300 novel amplitude in remitted CHR subjects was comparable to HC, and it was higher than that in CHR subjects who converted to psychosis or who did not remit. Thus, reduced P300 novel amplitude indexing impaired salience processing marked both conversion to psychosis and remission from psychotic symptoms.