ENZYMATIC CYCLIZATION OF NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE (NADP)
ENZYMATIC CYCLIZATION OF NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE (NADP)
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DOI：
10.1016/0960-894x(95)00393-8
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发表时间：
1995-10-05
影响因子：
2.7
通讯作者：
SIH, CJ
中科院分区：
文献类型：
--
作者：
ZHANG, FJ;GU, QM;SIH, CJ
加州相思的ADP-核糖基环化酶催化NADP、3 '-NADP和2'，3 '-环NADP转化成其相应的环核苷酸（通过NMR、UV和MS分析确定）。在大鼠脑微粒体系统中，环腺苷二磷酸核糖磷酸（cADPRP）比cADPR更有效地动员钙; cADPRP和cADPR的EC（50）分别为9.2 μ M和22 μ M。
The ADP-ribosyl cyclase of Aplysia californica catalyzed the conversion of NADP, 3'-NADP and 2',3'-cyclic NADP into their corresponding cyclic nucleotides (established by NMR, UV, and MS analyses). Cyclic-ADP-ribose-phosphate (cADPRP) was more potent than cADPR in mobilizing calcium in the rat brain microsomal system; the EC(50) for cADPRP and cADPR were 9.2 mu M and 22 mu M respectively.