Aberrations in normal systemic lipid metabolism in ovarian cancer patients
Aberrations in normal systemic lipid metabolism in ovarian cancer patients
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DOI：
10.1006/gyno.1996.0008
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发表时间：
1996-01-01
影响因子：
4.7
通讯作者：
Taylor, DD
中科院分区：
文献类型：
--
作者：
GercelTaylor, C;Doering, DL;Taylor, DD
许多研究已经证明了癌症患者中改变的全身脂质代谢，以及肿瘤细胞的异常脂质利用。这些个体中改变的全身脂质代谢的最常见量度是高脂血症。尽管恶病质通常不被认为与妇科癌症相关，但该研究证明了促进脂解活性的存在。在卵巢癌患者的血清和腹水中以及改变的全身脂质代谢的指标中可检测到升高的脂解促进活性，在7/9名患者的血清中和5/5名患者的腹水中可检测到升高的脂解促进活性。由于先前的研究表明癌症患者表现出与正常对照相比2.5倍的脂肪敏感性脂肪酶（HSL）增强，作为脂肪分解升高的潜在机制，检查了腹水衍生因子诱导HSL的能力。四种腹水中的三种的添加增加了正常脂肪细胞中的HSL水平。与正常腹膜液相比，所有患者的样本均表现出脂质水平升高。对三名卵巢癌患者的脂质进行分离和分析，发现与正常腹膜液相比，四项脂质参数发生了一致的变化：甘油单酯、甘油二酯和游离脂肪酸升高，甘油三酯降低。虽然“经典"恶病质不是卵巢癌的常见特征，但通常在恶病质个体中观察到的循环脂解促进活性和脂质代谢改变的存在，可以在这些卵巢癌患者中得到证实。基于最近的证据表明，在致癌启动或促进作用的脂质，肿瘤衍生的脂解促进因子和脂质代谢的改变的存在下，可能提供了一种机制，流行病学观察到的脂质和某些癌症，包括卵巢癌之间的关联。(C)出版社：Academic Press，Inc.
Numerous investigations have demonstrated altered systemic lipid metabolism in cancer patients, as well as aberrant lipid utilization by tumor cells, The most common measure of altered systemic lipid metabolism in these individuals has been hyperlipidemia, Although cachexia is not generally considered to be associated with gynecologic cancers, this study demonstrates the presence of lipolysis-promoting activity, detectable in sera and ascites of ovarian cancer patients and indices of altered systemic lipid metabolism, Elevated lipolysis promoting activity was detectable in the sera of 7/9 patients and in the ascites of 5/5 patients. Since previous studies have indicated that cancer patients exhibit a 2.5-fold enhancement in hormone-sensitive lipase (HSL) versus normal controls, as a potential mechanism for elevated lipolysis, the ability of ascites-derived factors to induce HSL was examined, The addition of three of four ascites fluids increased the level of HSL in normal adipocytes. All of the patients' samples exhibited elevated lipid levels versus normal peritoneal fluid. Isolation and analysis of lipids from three ovarian cancer patients revealed four consistent altered lipid parameters compared to normal peritoneal fluid: elevated monoglycerides, diglycerides, and free fatty acids and decreased triacylglycerides, While ''classical'' cachexia is not a common feature of ovarian cancer, the presence of circulating lipolysis-promoting activity and altered lipid metabolism, generally observed in cachectic individuals, can be demonstrated in these ovarian cancer patients. Based on recent evidence indicating a role of lipids in carcinogenic initiation or promotion, the presence of tumor-derived lipolysis-promoting factor and lipid metabolism alterations may provide a mechanism for the epidemiologically observed association between lipids and certain cancers, including ovarian cancer. (C) 1996 Academic Press, Inc.