THE CONCEPT OF HERD-IMMUNITY AND THE DESIGN OF COMMUNITY-BASED IMMUNIZATION PROGRAMS
THE CONCEPT OF HERD-IMMUNITY AND THE DESIGN OF COMMUNITY-BASED IMMUNIZATION PROGRAMS
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DOI：
10.1016/0264-410x(92)90327-g
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发表时间：
1992-01-01
期刊：
影响因子：
5.5
通讯作者：
ANDERSON, RM
中科院分区：
文献类型：
--
作者：
ANDERSON, RM
本文件侧重于传播成功和群体免疫的概念及其与社区免疫方案设计的相关性，以控制传染病。回顾了最近在若干领域开展的工作，包括大规模接种疫苗对感染平均年龄和感染和接种引起的发病率的影响、发展中国家的易感年龄窗口和疫苗方案设计问题、疫苗效力和疫苗安全性之间的相互作用以及控制性传播感染的疫苗接种方案的设计。讨论的重点是了解感染的传播动态与设计以社区为基础的控制方案之间的相互作用。
The paper focuses on the concepts of transmission success and herd immunity and their relevance to the design of community-based immunization programmes for the control of infectious diseases. Recent work in a number of areas is reviewed, including the influence of mass vaccination on the average age of infection and the incidence of morbidity due to infection and vaccination, the age window of susceptibility and the problems of vaccine programme design in developing countries, the interaction between vaccine efficacy and vaccine safety and the design of vaccination programmes for the control of sexually transmitted infections. Discussions centre on the interplay between an understanding of the transmission dynamics of an infection and the design of community-based control programmes.