Ovarian cancer: involvement of the matrix metalloproteinases.
Ovarian cancer: involvement of the matrix metalloproteinases.
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DOI：
10.1530/rep-14-0546
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Curry TE Jr
中科院分区：
文献类型：
--
作者：
Al-Alem L;Curry TE Jr
卵巢癌是妇科恶性肿瘤死亡的主要原因。与卵巢癌相关的高死亡率的原因包括晚期诊断，此时癌症已经转移到整个腹膜腔。癌转移是通过被称为基质金属蛋白酶（MMP）的蛋白水解酶家族重塑细胞外肿瘤基质而促进的。MMP家族中有23个成员，其中许多已被报道与卵巢癌相关。在目前的模式中，卵巢肿瘤细胞和周围的基质细胞刺激各种MMP的合成和/或活化，以帮助肿瘤生长，侵袭和最终转移。这篇综述阐明了不同类型卵巢癌中不同的MMPs及其对这种妇科恶性肿瘤进展的影响。
Ovarian cancer is the leading cause of death from gynecologic malignancies. Reasons for the high mortality rate associated with ovarian cancer include a late diagnosis at which time the cancer has metastasized throughout the peritoneal cavity. Cancer metastasis is facilitated by the remodeling of the extracellular tumor matrix by a family of proteolytic enzymes known as the matrix metalloproteinases (MMPs). There are 23 members in the MMP family, many of which have been reported to be associated with ovarian cancer. In the current paradigm, ovarian tumor cells and the surrounding stromal cells stimulate the synthesis and/or activation of various MMPs to aid in tumor growth, invasion, and eventual metastasis. This review sheds light on the different MMPs in the various types of ovarian cancer and their impact on the progression of this gynecologic malignancy.