Spatial and Functional Selectivity of Peripheral Nerve Signal Recording With the Transversal Intrafascicular Multichannel Electrode (TIME)
Spatial and Functional Selectivity of Peripheral Nerve Signal Recording With the Transversal Intrafascicular Multichannel Electrode (TIME)
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DOI：
10.1109/tnsre.2015.2440768
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Navarro, Xavier
中科院分区：
文献类型：
--
作者：
Badia, Jordi;Raspopovic, Stanisa;Navarro, Xavier
为生物医学应用选择合适的周围神经电极意味着在侵入性和选择性之间进行权衡。最佳设计应提供针对大量神经束的最高选择性，同时对神经的侵入性和潜在损伤最小。横向插入周围神经的横向束内多通道电极 (TIME) 已被证明可用于选择性激活大鼠小坐骨神经中束间和束内水平的轴突子集。在本研究中，我们评估了 TIME 选择性记录神经活动的能力，考虑了地形选择性和不同感觉类型对应的神经信号的区别。地形记录选择性通过对不同神经纤维亚群（例如支配大鼠后爪脚趾 2 和 4 的神经纤维）的 CNAP 的差异记录来证明。成功记录了施加于大鼠爪子的感觉刺激引起的神经信号。信号处理可以高性能地区分三种不同类型的感觉刺激，例如触觉刺激、本体感觉刺激和伤害性刺激。这些发现通过利用周围神经的横向拓扑结构，进一步支持了 TIME 在神经修复应用中的适用性。
The selection of suitable peripheral nerve electrodes for biomedical applications implies a trade-off between invasiveness and selectivity. The optimal design should provide the highest selectivity for targeting a large number of nerve fascicles with the least invasiveness and potential damage to the nerve. The transverse intrafascicular multichannel electrode (TIME), transversally inserted in the peripheral nerve, has been shown to be useful for the selective activation of subsets of axons, both at inter-and intra-fascicular levels, in the small sciatic nerve of the rat. In this study we assessed the capabilities of TIME for the selective recording of neural activity, considering the topographical selectivity and the distinction of neural signals corresponding to different sensory types. Topographical recording selectivity was proved by the differential recording of CNAPs from different subsets of nerve fibers, such as those innervating toes 2 and 4 of the hindpaw of the rat. Neural signals elicited by sensory stimuli applied to the rat paw were successfully recorded. Signal processing allowed distinguishing three different types of sensory stimuli such as tactile, proprioceptive and nociceptive ones with high performance. These findings further support the suitability of TIMEs for neuroprosthetic applications, by exploiting the transversal topographical structure of the peripheral nerves.