Habitual coughing and its associations with asthma, anxiety, and gastroesophageal reflux
Habitual coughing and its associations with asthma, anxiety, and gastroesophageal reflux
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DOI：
10.1378/chest.109.5.1262
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发表时间：
1996-05-01
期刊：
影响因子：
9.6
通讯作者：
Boman, G
中科院分区：
文献类型：
--
作者：
Ludviksdottir, D;Bjornsson, E;Boman, G
研究目的：研究咳嗽与不同疾病和指示气道炎症的客观变量的关系。背景：从瑞典乌普萨拉欧洲共同体呼吸健康调查的较大参与者群体中随机抽取 800 名年龄 20 至 44 岁的人作为样本；其中 623 人参加。该样本包含 201 名报告哮喘相关症状或使用哮喘药物的个体。 方法：该研究包括结构化访谈，包括有关习惯性（有痰和无痰）和夜间咳嗽和肺活量测定、乙酰甲胆碱激发、峰流量日记、皮肤点刺试验以及血液嗜酸性粒细胞计数和血清嗜酸性粒细胞阳离子蛋白 (S-ECP) 测量的问题。 结果：发现有痰咳嗽和哮喘之间存在显着的正相关性（调整后的比值比 [OR]=2.0）、过敏性鼻炎（OR=1.9）、胃食管反流（OR=4.4）、吸烟（OR=1.9）和焦虑（OR=1.8），而干咳与女性（OR=1.8）和焦虑（OR=1.7）有关。夜间咳嗽与女性（OR=1.8）、吸烟（OR=1.9）和哮喘（OR=2.2）呈正相关。支气管高反应性与咳痰呈正相关（p
Study objective: Coughing was studied in relation to different disorders and objective variables indicative of airway inflammation.Setting: A random sample of 800 persons, aged 20 to 44 years, was chosen from a larger cohort of participants in the European Community Respiratory Health Survey in Uppsala Sweden; of these, 623 participated. This sample was enriched with 201 individuals who reported asthma-related symptoms or the use of asthma medication.Methods: The study comprised a structured interview, including questions about habitual (productive and nonproductive) and nocturnal coughing and spirometry, methacholine challenge, peak flow diary, skin prick tests, and measurements of blood eosinophil count and serum eosinophil cationic protein (S-ECP).Results: A significant positive correlation was found between productive coughing and asthma (adjusted odds ratios [OR]=2.0), allergic rhinitis (OR=1.9), gastroesophageal reflux (OR=4.4), smoking (OR=1.9), and anxiety (OR=1.8), while nonproductive coughing was related to female gender (OR=1.8) and anxiety (OR=1.7). Nocturnal coughing was positively correlated to female gender (OR=1.8), smoking (OR=1.9), and asthma (OR=2.2). Bronchial hyperresponsiveness was positively related to productive coughing (p