The Human Hippocampus at 7 T-In Vivo MRI
The Human Hippocampus at 7 T-In Vivo MRI
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DOI：
10.1002/hipo.20487
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发表时间：
2009-01-01
期刊：
影响因子：
3.5
通讯作者：
Gizewski, E. R.
中科院分区：
文献类型：
--
作者：
Theysohn, Jens M.;Kraff, O.;Gizewski, E. R.
人类海马体在各种神经精神疾病中发挥着核心作用，例如颞叶癫痫（ME）、阿尔茨海默氏症、轻度认知障碍和精神分裂症。其体积、形态、内部结构和功能具有科学和临床意义。磁共振（MR）成像是神经放射学检查中广泛使用的工具，涉及脑解剖结构、（子）体积和脑功能（包括海马）的变化。由更高场强扫描仪提供的固有MR信号的增益和伴随的空间分辨率的改善似乎是非常有价值的。一个检查协议，允许完整的，高分辨率的人海马在7 T成像。采集冠状质子密度、T2、T2* 和液体衰减反转恢复对比度以及各向同性3D磁化准备的快速采集梯度回波（500 pm各向同性体素尺寸，非内插）。在可接受的扫描时间内观察能量沉积限制在薄的、基于自旋回波的切片的采集中仍然具有挑战性。与1.5 T相比，在7 T实现的更高分辨率下，海马体和一些内部特征（包括灰/白色物质分化和海马套的描绘）的分界变得更加可行;因此，在未来，这种成像技术可能有助于诊断细微的海马变化。(C)2008 Wiley-Liss，Inc.
The human hippocampus plays a central role in various neuropsychiatric disorders, such as temporal lobe epilepsy ME), Alzheimer's dementia, mild cognitive impairment, and schizophrenia. its volume, morphology, inner structure, and function are of scientific and clinical interest. Magnetic resonance (MR) imaging is a widely employed tool in neuroradiological workup regarding changes in brain anatomy, (sub-) volumes, and cerebral function including the hippocampus. Gain in intrinsic MR signal provided by higher field strength scanners and concomitant improvements in spatial resolution seem highly valuable. An examination protocol permitting complete, high-resolution imaging of the human hippocampus at 7 T was implemented. Coronal proton density, T2, T2*, and fluid-attenuated inversion recovery contrasts were acquired as well as an isotropic 3D magnetization-prepared rapid acquisition gradient-echo (500 pm isotropic voxel dimension, noninterpolated). Observance of energy deposition restrictions within acceptable scan times remained challenging in the acquisition of thin, spin-echo-based sections. At the higher resolution enabled by 7 T, demarcation of the hippocampus and some internal features including gray/white matter differentiation and depiction of the hippocampal mantle becomes much more viable when compared with 1.5 T; thus, in the future, this imaging technology might help in the diagnosis of subtle hippocampal changes. (C) 2008 Wiley-Liss, Inc.