Influence of Intensive Care Unit Enlightenment on Premature Infants on Functional Brain Maturation Assessed by Amplitude-Integrated Electroencephalograph
Influence of Intensive Care Unit Enlightenment on Premature Infants on Functional Brain Maturation Assessed by Amplitude-Integrated Electroencephalograph
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DOI：
10.1055/s-0039-1697681
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发表时间：
2021-03-01
影响因子：
2
通讯作者：
Aliefendioglu, Didem
中科院分区：
文献类型：
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作者：
Tandircioglu, Umit Ayse;Guzoglu, Nilufer;Aliefendioglu, Didem
目的振幅整合脑电图（aEEG）是一种有价值的早产儿脑功能发育的工具。然而，启蒙对早产儿功能性脑成熟的影响尚未被研究。我们的目的是这样做aEEG。研究设计共32名婴儿，30至35孕周，参与了这项研究。他们被随机分为三组，其中应用不同的照明协议。在第1组中，婴儿保育箱被覆盖24小时。在第2组中，婴儿保育箱开放24小时。在第三组中，婴儿保育箱被覆盖12小时，然后再打开12小时。婴儿在第3天（第一次测量）和第10天（第二次测量）进行aEEG记录沿着进行Burdjalov评分。结果第1组的睡眠-觉醒周期（SWC）、上、下缘振幅、窄带振幅、宽带振幅、SWC带宽在第1次测量时均高于其他各组（p = 0.042），第2次测量时差异无显著性（p = 0.110）。第10天，第1组和第3组的Burdjalov评分较高，但无统计学显著性（p = 0.871）。按孕周重新评估时，小于34周的两组婴儿Burdjalov评分（30-31周和32-33周）相似，34 ~ 35周组较对照组高。结论两组间首次测量窄带低幅值的差异可能反映了宫内环境的影响而不是在同一胎龄时开悟，因为它是在第三天做的。然而，所有组在第10天都有类似的结果，这表明重症监护环境中的其他因素可能会削弱启蒙的效果。Burdjalov评分与成熟相关，在34- 35周组中发现的高分表明，34周的成熟可能是我们组样本中SWC和发育的阈值。
Objective Amplitude-integrated electroencephalograph (aEEG) presents a valuable tool for functional brain maturation of preterm infants. However, the effect of enlightenment on functional brain maturation of premature infants has not been investigated. We aimed to do this with aEEG.Study Design A total of 32 infants, 30 to 35 gestational weeks, were involved in the study. They were randomly distributed into three groups in which different lighting protocols were applied. In group 1, the infants' incubators were covered for 24 hours. In group 2, the infants' incubators were open for 24 hours. In group 3, the infants' incubators were covered for 12 hours and open for another 12 hours. The infants are evaluated with aEEG recordings done on the 3rd (first measurement) and 10th days (second measurement) along with the Burdjalov scoring. Analysis of aEEG recordings was performed, based on sleep-wake cycles (SWCs), upper and lower margin amplitudes, narrowband and broadband of SWC, and bandwidth of SWC.Results At first, the narrowband lower amplitudes in group 1 were higher than those of the other groups (p = 0.042), but the difference was not significant in the second measurement (p = 0.110). The Burdjalov scores were higher in group 1 and group 3 on 10th day, though not statistically significant (p = 0.871). When the infants were reevaluated according to the gestational weeks, the Burdjalov scores of the two groups less than 34 weeks (30-31 and 32-33 weeks) were similar, whereas 34 to 35 weeks were higher when compared with those of the two groups.Conclusion The difference observed between groups in terms of narrowband lower amplitude in the first measurement may reflect the effect of intrauterine environment rather than enlightenment at the same gestational age because it was made on the third day. However, the fact that all groups have similar results on day 10 suggests that other factors in the intensive care setting may diminish the effect of enlightenment. Burdjalov scores are associated with maturation, and high scores found in the 34- to 35-week group suggest that the 34-week maturation might be a threshold for SWC and development in our group sample.