Expression of sialyl Lewis(a) as a new prognostic factor for patients with advanced colorectal carcinoma.
Expression of sialyl Lewis(a) as a new prognostic factor for patients with advanced colorectal carcinoma.
复制标题
唾液酸Lewis(a)的表达作为晚期结直肠癌患者新的预后因素。
作者：
T. Nakayama;M. Watanabe;T. Katsumata;T. Teramoto;M. Kitajima
背景
唾液酸路易斯（a）抗原（SLA）被认为是一种与癌症相关的碳水化合物抗原。
方法
使用识别 SLA 的单克隆抗体 (NS19-9) 对总共 309 个手术切除的原发性结直肠癌标本和 501 个相关的区域淋巴结转移样本进行了免疫组织化学分析。这些标本于 1981 年至 1988 年在庆应义塾大学医学院外科（日本东京）获得。
结果
在 75.4% (233/309) 的原发肿瘤和 78.5% (99/126) 的区域淋巴结转移瘤中检测到唾液酸路易斯 (a) 抗原表达。区域淋巴结转移中的表达明显强于原发灶（P = 4.5E-7）。通过单变量分析确定，原发肿瘤中唾液酸Lewis(a)抗原的表达与区域淋巴结转移(P < 0.005)、复发(P < 0.005)和术后生存(P < 0.001)显着相关。区域淋巴结转移中的唾液酸路易斯（a）抗原表达也与复发（P < 0.005）和生存（P < 0.01）密切相关。通过多变量分析确定，原发肿瘤中的 SLA 表达与复发 (P = 3.0E-6) 和生存 (P = 6.9E-3) 密切相关。
结论
原发性肿瘤和区域淋巴结转移中的唾液酸路易斯（a）抗原表达是评估晚期结直肠癌患者肿瘤侵袭性和预后的有用标志物。
BACKGROUND
Sialyl Lewis(a) antigen (SLA) is considered to be a cancer-associated carbohydrate antigen.
METHODS
A total of 309 surgically resected primary colorectal cancer specimens and 501 associated metastases to regional lymph nodes were analyzed immunohistochemically using a monoclonal antibody (NS19-9) recognizing SLA. The specimens were obtained from 1981 to 1988 at the Department of Surgery, Keio University School of Medicine (Tokyo, Japan).
RESULTS
Sialyl Lewis(a) antigen expression was detected in 75.4% (233/309) of the primary tumors and in 78.5% (99/126) of the metastases to regional lymph nodes. Significantly stronger expression was noted in the regional lymph node metastases than in the primary lesions (P = 4.5E-7). Sialyl Lewis(a) antigen expression in the primary tumors correlated significantly with regional lymph node metastasis (P < 0.005), recurrence (P < 0.005), and postoperative survival (P < 0.001) as determined by univariate analysis. Sialyl Lewis(a) antigen expression in the regional lymph node metastases also correlated strongly with recurrence (P < 0.005) and survival (P < 0.01). As determined by multivariate analysis, SLA expression in the primary tumor correlated strongly with recurrence (P = 3.0E-6) and survival (P = 6.9E-3).
CONCLUSIONS
Sialyl Lewis(a) antigen expression in primary tumors and metastases to regional lymph nodes is a useful marker for evaluating tumor aggressiveness and prognosis in patients with advanced colorectal cancer.