[Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides (author's transl)].
[Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides (author's transl)].
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[γ-谷维素对更年期紊乱的临床效果 - 对血清脂质过氧化物的影响（作者翻译）]。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
N. Ueno
中科院分区：
文献类型：
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作者：
M. Ishihara;Y. Ito;T. Nakakita;T. Maehama;S. Hieda;K. Yamamoto;N. Ueno
几十年来，γ -谷米醇作为一种自主药物在各个领域得到了广泛的应用，但近年来其对脂质代谢的影响越来越受到人们的关注。我们研究了γ -谷维素对更年期紊乱的影响，以及对脂质过氧化物水平差异的影响，脂质过氧化物与许多衰老综合征有着重要而不可或缺的联系。我们从40名受试者中获得了以下结果，这些受试者在服用1.5 g γ -米zanol细颗粒（含γ -米zanol 300 mg） 4至8周后出现更年期障碍。1. 90%的病例总体好转；优秀16个（40%），良好14个（35%），有效6个（15%），不变4个（10%）。2. 采用Kupperman法和Ueda法判断对更年期干扰的影响；一般回收率为85%、80%。3. 在高脂血症（TC大于等于220 mg/dl， TG大于等于140 mg/dl， HDL-chol）的病例中，总胆固醇、甘油三酯和HDL-chol显著降低。小于或等于45毫克/分升)。因此，动脉粥样硬化指数得到了很好的恢复。4. 在更年期紊乱的病例中，脂质过氧化物水平较高，经γ -谷维素治疗后，脂质过氧化物水平明显恢复。5. 在本研究中，未发现任何副作用，功能测试也未发现特别的变化。因此，我们证实了γ -谷米醇在更年期紊乱和脂质代谢方面的疗效和效用。
Though gamma-Oryzanol has been applicated as the autonomic agent in various fields for a few decades, recently its effect on lipid metabolism comes to be much more interested. We studied on the effect of gamma-Oryzanol on climacteric disturbance, and besides on the difference of lipid peroxides level which has an important and indispensable connection with mary syndromes involving aging. We obtained the following results from 40 subjects with climacteric disturbance after administration of gamma-Oryzanol Fine Particule 1.5 g (gamma-Oryzanol 300 mg included) for 4 to 8 weeks. 1. 90% of the cases improved generally; Excellent 16 (40%), Good 14 (35%), Effective 6 (15%), No change 4 (10%). 2. Effect on climacteric disturbance was judged by the Kupperman method and the Ueda method; generally recovered 85%, 80% each. 3. Significantly reduced total cholesterol, triglyceride and increased HDL-cholesterol were noted in cases with hyperlipidemia (TC greater than or equal to 220 mg/dl, TG greater than or equal to 140 mg/dl, HDL-chol. less than or equal to 45 mg/dl). Therefore, atherogenic index was excellently recovered. 4. In cases with climacteric disturbance lipid peroxides level was high, and they were significantly recovered by administration of gamma-Oryzanol. 5. During this study, no side effects have been recognized and no particular change in function test was found. Thus, we confirmed the efficacy and utility of gamma-Oryzanol on many complaints in climacteric disturbance and also on lipid metabolism.