Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
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DOI：
10.1038/s41467-019-10864-z
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发表时间：
2019-07-15
影响因子：
16.6
通讯作者：
Wei, Yingying
中科院分区：
文献类型：
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作者：
Luo, Xiangyu;Yang, Can;Wei, Yingying
在表观基因组关联研究中，每个样品的测量信号是来自不同细胞类型的甲基化谱的混合物。目前的关联检测方法要求胞嘧啶-磷酸-鸟嘌呤（CpG）位点是否与表型相关或不相关，并可能遭受低统计功率。在这里，我们提出了一种统计方法，HIGh REsolution（HIRE），与现有方法相比，它不仅提高了总体水平上的关联检测能力，而且还能够检测单个细胞类型的风险CpG位点。
In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. Current approaches to the association detection claim whether a cytosine-phosphate-guanine (CpG) site is associated with the phenotype or not at aggregate level and can suffer from low statistical power. Here, we propose a statistical method, HIgh REsolution (HIRE), which not only improves the power of association detection at aggregate level as compared to the existing methods but also enables the detection of risk-CpG sites for individual cell types.