ECTOPIC PITUITARY TRANSPLANTS RESTORE IMMUNOCOMPETENCE IN AMES DWARF MICE
ECTOPIC PITUITARY TRANSPLANTS RESTORE IMMUNOCOMPETENCE IN AMES DWARF MICE
复制标题
DOI：
10.1530/acta.0.1250067
复制
发表时间：
1991-07-01
期刊：
影响因子：
--
通讯作者：
BARTKE, A
中科院分区：
文献类型：
--
作者：
ESQUIFINO, AI;VILLANUA, MA;BARTKE, A
本研究旨在探讨催乳素对艾姆斯侏儒小鼠免疫功能的影响。为此，在成年艾姆斯侏儒小鼠的肾包膜下植入正常小鼠的垂体。与假手术侏儒小鼠或未处理的正常小鼠相比，异位垂体移植使雄性和雌性侏儒小鼠的血浆催乳素水平产生预期的增加。体重显着增加垂体移植侏儒小鼠的两种性别，但没有达到正常（非侏儒）动物中发现的值。与假手术侏儒对照组相比，Paphylococcus移植诱导了侏儒小鼠胸腺重量和胸腺中淋巴细胞数量的增加。移植侏儒小鼠的胸腺重量仍低于正常小鼠的值，而胸腺淋巴细胞的数量变得与正常小鼠的记录难以区分。垂体移植对脾脏的影响与胸腺的影响相似;然而，垂体移植侏儒小鼠的重量和淋巴细胞数量均未达到正常动物的值。垂体移植的雄性和雌性侏儒小鼠的脾淋巴细胞的自然杀伤活性大大增强相比，从假手术侏儒的淋巴细胞。这种影响在男性中大于女性。垂体移植的雄性侏儒小鼠的白色血细胞数量增加，与正常雄性小鼠的值难以区分。令人惊讶的是，这种影响在女性中并不存在。这些发现表明，移植物分泌的激素，最有可能是催乳素和生长激素，可以增强免疫反应。这种作用可能是由催乳素和/或生长激素对免疫细胞的直接作用或间接作用介导的。
This work was undertaken to study the effects of prolactin on immune function in Ames dwarf mice. For that purpose, adult Ames dwarf mice were implanted with pituitaries from normal mice under the kidney capsule. Ectopic pituitary transplants produced the expected increase in plasma prolactin levels in male and female dwarf mice as compared to sham-operated dwarf or untreated normal mice. Body weight was significantly increased in pituitary-grafted dwarf mice of both sexes, but did not reach the values found in normal (non-dwarf) animals. Pituitary transplants induced an increase in thymus weight and in the number of lymphocytes in the thymus in dwarf mice of both sexes as compared to sham-operated dwarf controls. The weight of the thymus in grafted dwarf mice remained below values found in normal mice, while the number of thymic lymphocytes became indistinguishable from those recorded in normal mice, Effects of pituitary transplants on the spleen were similar to those described for the thymus; however, neither the weight nor the lymphocyte number in pituitary-grafted dwarfs reached the values found in normal animals. Natural killer activity of spleen lymphocytes from pituitary-grafted male and female dwarf mice was greatly enhanced as compared to lymphocytes from sham-operated dwarfs. This effect was greater in males than in females. The number of white blood cells in pituitary-grafted male dwarf mice was increased and indistinguishable from the values found in normal males. Surprisingly, this effect was absent in the females. These findings suggest that hormones secreted by the transplants, most likely prolactin and growth hormone, can enhance the immune response. This action may be mediated by direct action of prolactin and/or growth hormone on immune cells or by indirect effects.