Identifying suicidal subtypes and dynamic indicators of increasing and decreasing suicide risk in active duty military personnel: Study protocol.
Identifying suicidal subtypes and dynamic indicators of increasing and decreasing suicide risk in active duty military personnel: Study protocol.
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DOI：
10.1016/j.conctc.2021.100752
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发表时间：
2021-03
影响因子：
1.5
通讯作者：
STRONG STAR Consortium
中科院分区：
文献类型：
--
作者：
Brown LA;Bryan CJ;Butner JE;Tabares JV;Young-McCaughan S;Hale WJ;Fina BA;Foa EB;Resick PA;Taylor DJ;Coon H;Williamson DE;Dondanville KA;Borah EV;McLean CP;Wachen JS;Pruiksma KE;Hernandez AM;Litz BT;Mintz J;Yarvis JS;Borah AM;Nicholson KL;Maurer DM;Kelly KM;Peterson AL;STRONG STAR Consortium
最近的几项研究表明，创伤后应激障碍（PTSD）和失眠治疗与军人自杀意念（SI）的显着减少有关。然而，很少有研究评估了接受创伤后应激障碍或失眠治疗的军人自杀风险随时间变化的方式。本文描述了一个项目的研究方案，该项目的目的是：（1）在一个大型的部署服务人员队列中探索潜在的自杀风险的遗传、临床和人口统计学亚型;（2）探索创伤后应激障碍和失眠症的循证心理治疗导致的SI亚型变化;（3）评估自杀风险的变化速度;以及（4）确定自杀风险较高和较低的预测因素。现役军人被招募参加四项临床试验（三项用于创伤后应激障碍治疗，一项用于失眠治疗）和一项针对部署服务人员的大型前瞻性流行病学研究，所有这些都是通过南德克萨斯州创伤和复原力研究组织网络指导研究（STRONG星星联盟）进行的。参与者完成了类似的人口统计学和临床特征测量，并提供了用于基因检测的血液样本。我们将分析的主要措施是贝克自杀意念量表，贝克抑郁量表和DSM-IV的PTSD检查表。这项研究的结果将提供新的见解，以了解现役人员中自杀风险的离散亚型的存在，这些亚型中风险随时间的变化以及亚型的预测因素。研究结果将为有自杀风险的军人提供治疗开发信息。
Several recent studies have demonstrated that posttraumatic stress disorder (PTSD) and insomnia treatments are associated with significant reductions in suicidal ideation (SI) among service members. However, few investigations have evaluated the manner in which suicide risk changes over time among military personnel receiving PTSD or insomnia treatments. This paper describes the study protocol for a project with these aims: (1) explore potential genetic, clinical, and demographic subtypes of suicide risk in a large cohort of deployed service members; (2) explore subtype change in SI as a result of evidence-based psychotherapies for PTSD and insomnia; (3) evaluate the speed of change in suicide risk; and (4) identify predictors of higher- and lower-risk for suicide. Active duty military personnel were recruited for four clinical trials (three for PTSD treatment and one for insomnia treatment) and a large prospective epidemiological study of deployed service members, all conducted through the South Texas Research Organizational Network Guiding Studies on Trauma and Resilience (STRONG STAR Consortium). Participants completed similar measures of demographic and clinical characteristics and subsets provided blood samples for genetic testing. The primary measures that we will analyze are the Beck Scale for Suicide Ideation, Beck Depression Inventory, and the PTSD Checklist for DSM-IV. Results from this study will offer new insights into the presence of discrete subtypes of suicide risk among active duty personnel, changes in risk over time among those subtypes, and predictors of subtypes. Findings will inform treatment development for military service members at risk for suicide.
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
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通讯作者：
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