Course of chronic focal epilepsy resistant to anticonvulsant treatment
Course of chronic focal epilepsy resistant to anticonvulsant treatment
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DOI：
10.1053/seiz.2000.0499
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发表时间：
2001-06-01
影响因子：
3
通讯作者：
Burr, W
中科院分区：
文献类型：
--
作者：
Bauer, J;Burr, W
对63名长期服用卡马西平、苯妥英、丙戊酸盐和/或苯巴比妥的患者（32名女性，31名男性）进行了研究。癫痫发作的平均年龄为16.4岁；记录癫痫发作频率的平均起始年龄为33.7岁；平均随访时间为104.8个月；每名患者记录的癫痫发作平均次数为313.2次。对癫痫发作日记进行了统计分析。每天记录的是每天的癫痫发作次数。计算了线性趋势，即癫痫发作频率与随机分布事件相比的方差量，并将所得系数拟合到一般线性回归模型中。还寻找了非随机聚集（簇）以及癫痫发作表现的间隙。在癫痫病程中，癫痫发作频率减少（30%）或增加（29%）的患者数量相近。大多数患者（78%）每日癫痫发作频率的方差明显高于或低于（5%）相应的随机分布。57%的患者与前一天的耦合系数显著大于零（表明癫痫发作聚集）。在31名患者（包括男性和女性）中发现癫痫发作情况存在显著的节律成分（准每周或准每月）。62%的患者出现癫痫发作频率增加的时期（簇）；29名患者出现至少1年的癫痫发作间隙，其中20名患者随后癫痫复发。总之，没有证据表明服用抗癫痫药物的慢性局灶性癫痫患者存在一种独特的病程类型。（C）2001年BEA贸易有限公司
Sixty-three patients (32 women, 31 men), chronically treated with carbamazepine, phenytoin, valproate and/or phenobarbital, were investigated. Mean age at manifestation of epilepsy was 16.4 years; mean age at onset of documentation of seizure frequency was 33.7 years; mean duration of follow-up was 104.8 months; mean number of documented seizures per patient was 313.2. A statistical analysis of seizure diaries was performed. For each day the entries were the number of seizures per day. Linear trends, the amount of variance of the seizure frequency compared to randomly distributed events, were computed with the resulting coefficients fitting a general linear regression model. Non-random aggregations (clusters) were searched for as well as gaps of seizure manifestation. A similar number of patients exhibited a decrease (30%) or increase (29%) of seizure frequency during the course of epilepsy. The variance of the daily seizure frequency was in most patients (78%) significantly higher or lower (5%) than corresponding random distributions. The coupling coefficient to the day before was significantly larger than zero (indicating seizure clustering) in 57% of patients. Significant rhythmic components in seizure profiles (quasi-weekly or quasi-monthly) were found in 31 patients (both male and female). Periods of increased seizure frequency (clusters) manifested in 62% of patients; seizure gaps of at least 1 year occurred in 29 patients followed by seizure relapses in 20 patients. In conclusion, there is no evidence for a unique type of course in chronic focal epilepsy in patients on antiepileptic drugs. (C) 2001 BEA Trading Ltd.