Association of Oncogenic and Nononcogenic Human Papillomavirus With HIV Incidence
Association of Oncogenic and Nononcogenic Human Papillomavirus With HIV Incidence
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DOI：
10.1097/qai.0b013e3181b327e7
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Taljaard, Dirk
中科院分区：
文献类型：
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作者：
Auvert, Bertran;Lissouba, Pascale;Taljaard, Dirk
目的：鲜为人知的是人乳头瘤病毒（HPV）和HIV之间的相互作用。这项研究的目的是探讨致癌（高风险）和非致癌（低风险）HPV与HIV incidence.Methods的关联：我们使用了1683尿道拭子收集在最后一次随访的男性包皮环切术试验进行橙子农场（南非）。拭子分析和HPV基因分型进行聚合酶链反应。我们使用生存分析估计了HIV调整的发病率比（aIRR）和95%置信区间（CI）。结果：HR和LR HPV的感染率分别为14.0%（95%CI：12.4 ~ 15.7）和17.3%（95%CI：15.6 ~ 19.2）。当控制HR-HPV状态时，LR-HPV状态与HIV发病率无关（aIRR = 1.13，95%CI：0.40 - 3.16; P = 0.82）。当控制所有协变量时，HIV感染率随HR-HPV阳性率（aIRR = 3.76，95% CI：1.83 ~ 7.73，P < 0.001）和HR-HPV基因型数（调整后P线性趋势= 0.0074）的增加而显著增加。一个是HR-HPV促进HIV感染。HPV与HIV感染的关系需要进一步研究。
Objective: Little is known about the interaction between human papillomavirus (HPV) and HIV This study aimed to explore the association of oncogenic (high risk) and nononcogenic (low risk) HPV with HIV incidence.Methods: We used 1683 urethral swabs collected at the last follow-up visit of a male circumcision trial conducted in Orange Farm (South Africa). Swabs analyses and HPV genotyping were performed by polymerase chain reaction. We estimated HIV adjusted incidence rate ratios (aIRRs) and 95% confidence intervals (CIs) using survival analysis. Background characteristics, male circumcision status, sexual behavior, HPV status, and other sexually transmitted infections were used as covariates.Results: The prevalence of HR and LR HPV was 14.0% (95% CI: 12.4 to 15.7) and 17.3% (95% Cl: 15.6 to 19.2), respectively. When controlling for HR-HPV status, LR-HPV status was not associated with HIV incidence (aIRR = 1.13, 95% CI: 0.40 to 3.16; P = 0.82). When controlling for all covariates, HIV incidence increased significantly with HR-HPV positivity (aIRR = 3.76, 95% CI: 1.83 to 7.73, P < 0.001) and with the number of HR-HPV genotypes (adjusted-P linear trend = 0.0074).Conclusions: Several explanations could account for our findings. One is that HR-HPV facilitates HIV acquisition. The association of HPV with HIV acquisition requires further investigations.