MALIGNANT-MELANOMA IN RELATION TO MOLES, PIGMENTATION, AND EXPOSURE TO FLUORESCENT AND OTHER LIGHTING SOURCES
MALIGNANT-MELANOMA IN RELATION TO MOLES, PIGMENTATION, AND EXPOSURE TO FLUORESCENT AND OTHER LIGHTING SOURCES
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DOI：
10.1038/bjc.1986.10
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发表时间：
1986-01-01
影响因子：
8.8
通讯作者：
STAPLETON, PJ
中科院分区：
文献类型：
--
作者：
ELWOOD, JM;WILLIAMSON, C;STAPLETON, PJ
对83名恶性黑色素瘤患者进行了访谈，占33个月来居住在诺丁汉特定地区的所有NHS新患者的74%，并从具有相同居住地的同一医院的所有门诊和住院患者中选择了年龄和性别匹配的对照组。研究发现，上臂有3颗或更多隆起的痣的受试者患黑色素瘤的风险显著增加(相对风险=17.0)，与面部和手臂上严重的雀斑有关，以及容易晒伤和晒黑的倾向，这些因素具有独立的影响。虽然没有发现与暴露在荧光灯下的显著和一致的联系，但暴露在更大剂量的受试者中观察到的风险更高，与未扩散的光暴露的相关性比与扩散光暴露的风险更高。与对照组相比，患者暴露在未扩散光中的小时数显著增加。与随后的邮寄问卷相比，基于采访数据的调查与荧光灯暴露的关联性更强。21个病例和11个对照报告接触了可能含有紫外线成分的不寻常的职业光源；这些光源包括各种强烈的光源以及用于印刷和Dyeline复印的灯。
Interviews were performed on 83 patients with malignant melanoma, being 74% of all new NHS patients over a 33 month period who were resident in a defined area of Nottingham, and on age and sex matched controls chosen from all outpatients and inpatients of the same hospitals with the same area of residence. Significantly increased risks of melanoma were found in subjects with 3 or more raised moles on the upper arms (relative risk = 17.0), in association with heavy freckling of the face and arms, and with a tendency to sunburn easily and tan poorly, these factors having independent effects. While no significant and consistent association with exposure to fluorescent light was seen, the observed risks were higher in subjects with greater exposure, and higher in association with exposure to undiffused than to diffused light. Cases had a significantly greater number of hours'' exposure to undiffused light than did controls. The associations with fluorescent light exposure were stronger when based on interview data than on a subsequent postal questionnaire. Twenty-one cases and 11 controls reported exposure to unusual occupational lighting sources which may have had an ultraviolet component; these included various intense lighting sources and lamps used in printing and dyeline copying.