Baroreceptor afferent discharge in the pregnant rat.
Baroreceptor afferent discharge in the pregnant rat.
复制标题
怀孕大鼠的压力感受器传入放电。
DOI：
10.1152/ajpregu.2000.278.6.r1433
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Hines,T
中科院分区：
文献类型：
--
作者：
Hines,T
妊娠与心脏和动脉压力感受器刺激的反射反应迟钝有关。我们测试的假设，动脉压力感受器传入放电衰减的压力刺激在怀孕的大鼠。麻醉后测定多纤维主动脉降压神经活动（ADNA）、平均动脉压（MAP）和心率。（戊巴比妥钠，35 mg/kg ip）晚期妊娠大鼠和未孕大鼠对增加[苯巴比妥（PE），1.5-24 μg/kg−1/min− 1和1-16 μg/kg]和减少[硝普钠（SNP），5-80 μg·kg-1·min-1和0.05-16 μg/kg]。妊娠大鼠静息MAP较低，但在PE和SNP给药期间MAP的变化与未孕大鼠相似。在PE和SNP输注期间，由于对压力刺激的更快适应，妊娠动物中的ADNA显著减弱（P< 0.05）。单次给药引起两组MAP和ADNA的变化相似;然而，在妊娠大鼠中，最低剂量的SNP使ADNA降低最大。因此，压力感受器传入放电减弱怀孕大鼠，这涉及到一个更快的适应压力刺激。
Pregnancy is associated with blunted reflex responses to cardiac and arterial baroreceptor stimulation. We tested the hypothesis that arterial baroreceptor afferent discharge is attenuated in response to a pressure stimulus in pregnant rats. Multifiber aortic depressor nerve activity (ADNA), mean arterial pressure (MAP), and heart rate were measured in anesthetized (pentobarbital sodium, 35 mg/kg ip) late-pregnant and virgin rats in response to increases [phenylephrine (PE), 1.5–24 μg ⋅ kg−1⋅ min−1and 1–16 μg/kg] and decreases [sodium nitroprusside (SNP), 5–80 μg ⋅ kg−1⋅ min−1and 0.05–16 μg/kg] in MAP. Resting MAP was lower in pregnant rats, but changes in MAP were similar to those in virgin rats during both PE and SNP administration. ADNA was significantly attenuated in pregnant animals during both PE and SNP infusions (P< 0.05) due to a more rapid adaptation to the pressure stimulus. Bolus drug administration evoked similar changes in MAP and ADNA in both groups; however, the maximum decrease in ADNA was achieved at the lowest dose of SNP in pregnant rats. Thus baroreceptor afferent discharge is attenuated in pregnant rats, and this involves a more rapid adaptation to a pressure stimulus.