Diabetes mellitus and progression of rigidity and gait disturbance in older persons
Diabetes mellitus and progression of rigidity and gait disturbance in older persons
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DOI：
10.1212/01.wnl.0000138432.16676.4b
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发表时间：
2004-09-28
期刊：
影响因子：
9.9
通讯作者：
Bennett, DA
中科院分区：
文献类型：
--
作者：
Arvanitakis, Z;Wilson, RS;Bennett, DA
背景：帕金森样症状，包括僵直、步态障碍和运动迟缓，在老年中是常见和进行性的，并与发病率和死亡率相关。这些症状的危险因素很少被确定。糖尿病也是一种常见的老年慢性疾病，已知与身体和神经功能障碍有关，可能与帕金森样症状有关。目的：探讨糖尿病与四种帕金森样体征的关系。方法：参与者为822名老年天主教神职人员和女性，他们在基线时没有临床诊断为帕金森病或痴呆。在长达9年的时间里，他们都有统一的年度评估，其中包括统一帕金森病评定量表的运动部分的修改版本，从先前建立的四种特定帕金森样症状的测量中得出。根据直接用药检查和病史，评估参与者是否存在糖尿病。结果：128名（15.6%）参与者患有糖尿病。在控制年龄、性别和教育程度的随机效应模型中，糖尿病与僵硬恶化有关
Background: Parkinsonian-like signs, including rigidity, gait disturbance, and bradykinesia, are common and progressive in old age and are associated with morbidity and mortality. Few risk factors for these signs have been identified. Diabetes mellitus, also a common chronic condition in old age and known to be associated with physical and neurologic disability, may be associated with parkinsonian-like signs. Objective: To examine the relation of diabetes to four parkinsonian-like signs. Methods: Participants were 822 older Catholic clergymen and women who were without clinically diagnosed Parkinson disease or dementia at baseline. For up to 9 years, they had uniform annual evaluations, which included a modified version of the motor portion of the Unified Parkinson's Disease Rating Scale, from which previously established measures of four specific parkinsonian-like signs were derived. Participants were evaluated for the presence of diabetes, based on direct medication inspection and history. Results: Diabetes was present in 128 (15.6%) participants. In random effects models controlling for age, sex, and education, diabetes was associated with worsening rigidity (p