The association between endothelial nitric oxide synthase gene G894T polymorphism and hypertension in Han Chinese: a case-control study and an updated meta-analysis
The association between endothelial nitric oxide synthase gene G894T polymorphism and hypertension in Han Chinese: a case-control study and an updated meta-analysis
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DOI：
10.3109/03014460.2014.911958
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发表时间：
2015-03-01
影响因子：
1.7
通讯作者：
Wen, Shaojun
中科院分区：
文献类型：
--
作者：
Liu, Jielin;Wang, Lijuan;Wen, Shaojun
背景资料：G894 T内皮型一氧化氮合酶rs 1799983基因多态性eNOS/NOS 3基因多态性与原发性高血压（EH）的易感性有一定关系，但在中国人群中尚未达成明确共识。首先对1525例北方汉族人群进行病例对照研究，研究G894 T变异与高血压的关系，然后对所有可用的汉族研究进行荟萃分析。共有25项研究，包括13443例受试者最终纳入本荟萃分析。结果：本病例对照研究未发现G894 T变异与北方汉族人群高血压的显著相关性。随后的Meta分析显示，该多态性可能与中国汉族人高血压相关（p
Background: The G894T (rs1799983) polymorphism in endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension (EH) in some studies, but no clear consensus has been reached in the Chinese population.Aims: This study aimed to investigate the association of the G894T polymorphism and EH in Han Chinese.Subjects and methods: First, a case-control study was performed involving 1525 subjects in northern Han Chinese to study the association between G894T variants and EH and then a meta-analysis was conducted of all available studies in Han Chinese. A total of 25 studies comprising 13 443 subjects were finally included in this meta-analysis. Results: The present case-control study failed to show significant association of G894T variant with EH in northern Han Chinese. The subsequent meta-analysis showed that this polymorphism might be associated with EH in Han Chinese (p