Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study
Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study
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DOI：
10.1136/jnnp.68.1.93
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发表时间：
2000-01-01
影响因子：
11
通讯作者：
Frisoni, GB
中科院分区：
文献类型：
--
作者：
Geroldi, C;Laakso, MP;Frisoni, GB
大脑结构的不对称性在许多物种中很常见，甚至在子宫内也存在。一些发育性、病理性和痴呆性疾病与正常解剖学不对称性的改变有关。然而，在阿尔茨海默病中，解剖学上的不对称性只得到了表面上的研究。最近的证据表明，载脂蛋白E（ApoE）的等位基因E14，一个众所周知的阿尔茨海默氏病的危险因素，可能在决定正常携带者和阿尔茨海默氏病患者的一些脑形态学变化中发挥作用。本研究评估了ApoE基因型对携带0、1和2个等位基因拷贝的阿尔茨海默病患者海马不对称性的影响。计算了28例右利手阿尔茨海默病患者（14 -/-，9例右利手4/-和5例右利手4/4）和30例无可检测到的认知缺陷的对照组的右利手campi的体积左右差异。在对照组中，右侧海马大于左侧，而在阿尔茨海默病患者中，这种不对称性随着α 4等位基因基因剂量的增加而逐渐减少，并且在α 4/4阿尔茨海默病组中逆转了不对称性。平均右-左体积差异分别为：对照组1.2、0.7、0.2和-1.0，-1-、104/-和104/4例患者分别为1.2、0.7、0.2和-1.0（趋势的性别校正p =0.017）。数据表明，剂量依赖性的影响，ApoE ε 4等位基因对海马体积不对称性阿尔茨海默病。
Asymmetry of brain structures is common to many species and is even present in utero. Some developmental, pathological, and dementing diseases are associated with alterations in normal anatomical asymmetries. Anatomical asymmetries, however, have been only superficially studied in Alzheimer's disease. Recent evidence indicates that the allele epsilon 4 of the apolipoprotein E (ApoE), a well known risk factor for Alzheimer's disease, might play a part in determining some brain morphological changes both in normal carriers and in patients with Alzheimer's disease. This study evaluated the effect of the ApoE genotype on hippocampal asymmetry in patients with Alzheimer's disease carrying 0, 1, and 2 copies of the allele. Volumetric right-left differences of the hippocampi were computed in 28 right handed patients with Alzheimer's disease (14 -/-, 9 epsilon 4/-, and 5 epsilon 4/4) and 30 controls without detectable cognitive deficit. In controls, the right hippocampus was larger than the left, whereas in patients with Alzheimer's disease this asymmetry was progressively reduced with increasing gene dose of the epsilon 4 allele, and asymmetry was reversed in the epsilon 4/4 Alzheimer's disease group. The mean right-left volume differences were: 1.2, 0.7, 0.2, and -1.0 in controls, -1-, epsilon 4/-, and epsilon 4/4 patients, respectively (sex adjusted p for trend=0.017). The data indicate a dose dependent effect of the ApoE epsilon 4 allele on hippocampal volume asymmetry in Alzheimer's disease.