Lymph Node Micrometastases in Early-Stage Cervical Cancer are Not Predictive of Survival
Lymph Node Micrometastases in Early-Stage Cervical Cancer are Not Predictive of Survival
复制标题
早期宫颈癌的淋巴结微转移并不能预测生存期
DOI：
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发表时间：
2015
影响因子：
2.4
通讯作者：
Mildred R. Chernofsky
中科院分区：
文献类型：
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作者：
M. Stany;P. Stone;J. Felix;C. Amezcua;S. Groshen;W. Ye;Kathy L. Kyser;R. Howard;C. Zahn;L. Muderspach;S. Lentz;Mildred R. Chernofsky
虽然早期宫颈癌患者一般预后良好，但根据病理危险因素，仍有10%至40%的患者复发。本研究的目的是评估淋巴结微转移（LNmM）的存在是否对患者的生存产生影响。我们对1994年至2004年期间接受根治性子宫切除术和盆腔淋巴结切除术治疗的淋巴结阴性的早期宫颈癌患者进行了多机构回顾性研究。重新切除患者原始手术的淋巴结组织块，然后评估微转移的存在。129名患者符合纳入标准。LNmM 26例（20%）。平均随访70个月，11例复发（8.5%）。在11例复发患者中，2例（18%）为LNmM。LNmM患者更有可能接受辅助放疗和化疗。在分层对数秩分析中，LNmM与任何其他高危临床或病理变量无关。生存数据分析没有显示LNmM的存在与复发或总生存之间的关联。LNmM的存在与不良预后无关，也与预测复发的其他高危临床或病理变量无关。微转移在宫颈癌中的作用有待进一步研究。
Although patients with early-stage cervical cancer have in general a favorable prognosis, 10% to 40% patients still recur depending on pathologic risk factors. The objective of this study was to evaluate if the presence of lymph node micrometastasis (LNmM) had an impact on patient’s survival. We performed a multi-institutional retrospective review on patients with early-stage cervical cancer, with histologically negative lymph nodes, treated with radical hysterectomy and pelvic lymphadenectomy for the study period 1994 to 2004. Tissue blocks of lymph nodes from the patient’s original surgery were recut and then evaluated for the presence of micrometastases. One hundred twenty-nine patients were identified who met inclusion criteria. LNmM were found in 26 patients (20%). In an average follow-up time of 70 mo, there were 11 recurrences (8.5%). Of the 11 recurrences, 2 (18%) patients had LNmM. Patients with LNmM were more likely to have received adjuvant radiation and chemotherapy. In stratified log-rank analysis, LNmM were not associated with any other high-risk clinical or pathologic variables. Survival data analysis did not demonstrate an association between the presence of LNmM and recurrence or overall survival. The presence of LNmM was not associated with an unfavorable prognosis nor was it associated with other high-risk clinical or pathologic variables predicting recurrence. Further study is warranted to understand the role of micrometastases in cervical cancer.
DOI：
10.1097/00006254-200008000-00017
发表时间：
2000-04
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
W. Peters;P. Liu;R. Barrett;R. Stock;B. Monk;J. Berek;L. Souhami;P. Grigsby;W. Gordon;
通讯作者：
W. Peters;P. Liu;R. Barrett;R. Stock;B. Monk;J. Berek;L. Souhami;P. Grigsby;W. Gordon;