High Throughput Screening of Glycopolymers: Balance between Cytotoxicity and Antibacterial Property
High Throughput Screening of Glycopolymers: Balance between Cytotoxicity and Antibacterial Property
复制标题
糖聚合物的高通量筛选：细胞毒性和抗菌性能之间的平衡
DOI：
10.1021/acsmacrolett.9b00091
复制
发表时间：
2019-03-01
影响因子：
7.015
通讯作者：
Chen, Gaojian
中科院分区：
文献类型：
--
作者：
Zheng, Yuqing;Luo, Yan;Chen, Gaojian
To search for synthetic agents with low cytotoxicity and good antibacterial activity is essential for antimicrobial applications. Here we report a high throughput technique that carried out in multiwell plates via recyclable-catalyst-aided, opened-to-air, and sunlight-photolyzed RAFT (ROS-RAFT) polymerization. By using this method, three key monomers (MAG the sugar unit, DMAPMA the positively charged monomer, and DEMAA the hydrophobic monomer) can be polymerized in a controlled manner to afford glycopolymers. This simple high throughput technology is used to synthesize glycopolymers with variable compositions. The bacterial adhesion/killing ability and cytotoxicity of synthesized polymers have been evaluated, and glycopolymers with certain composition can achieve and good antibacterial activity.
