Transfer Mechanism of Anthracycline Antibiotics and Their Ion‐Association with PAMAM Dendrimer at Liquid|Liquid Interfaces
Transfer Mechanism of Anthracycline Antibiotics and Their Ion‐Association with PAMAM Dendrimer at Liquid|Liquid Interfaces
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蒽环类抗生素的转移机制及其与 PAMAM 树枝状聚合物在液|液界面的离子缔合
DOI：
10.1002/celc.202200359
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发表时间：
2022
期刊：
影响因子：
4
通讯作者：
Nagatani Hirohisa
中科院分区：
文献类型：
--
作者：
Takami Toshinari;Kanai Shohei;Nishiyama Yoshio;Lee Hye Jin;Nagatani Hirohisa
研究了蒽环类抗生素多柔比星（DNR）和多柔比星（DOX）在水- 1,2 -二氯乙烷（DCE）界面上的转移反应。光谱电化学分析表明，蒽环类阳离子在裸水|DCE界面和具有磷脂层的仿生界面上的转移机制发生了显著变化，结构上略有不同。在仿生界面上hdrr +和HDOX+均具有促进离子转移的特征，其中HDOX+的吸附过程在界面的水侧，即磷脂层的极性头基区有很宽的电位范围。羧酸端端3.5代聚氨基胺（G3.5 PAMAM）树状大分子与蒽环类衍生物在中性pH条件下优先发生分子缔合。带负电荷的G3.5 PAMAM树状大分子诱导了蒽环类阳离子在水- | - DCE界面上的转移电位的正偏移，表明其作为电位和pH响应的药物载体的能力。
The transfer reaction of anthracycline antibiotics, daunorubicin (DNR) and doxorubicin (DOX), was investigated at the water|1,2‐dichloroethane (DCE) interface. Spectroelectrochemical analysis demonstrated significant changes in the transfer mechanism of anthracycline cations with a slight structural difference across the bare water|DCE interface and the biomimetic interface with a phospholipid layer. The facilitated ion transfer feature was found for both HDNR+and HDOX+at the biomimetic interface, where the adsorption process of HDOX+was observed over a wide potential range at the aqueous side of the interface, that is, the polar headgroup region of the phospholipid layer. The molecular association between the carboxylate‐terminated generation 3.5 polyamidoamine (G3.5 PAMAM) dendrimer and anthracycline derivatives occurred preferentially under neutral pH conditions. The negatively charged G3.5 PAMAM dendrimer induced positive shifts of the transfer potential of anthracycline cations at the water|DCE interface, indicating its ability as potential‐ and pH‐responsive drug carriers.