Theory of Microwell Arrays Performing as Generators-Collectors Based on a Single Bipolar Plane Electrode
Theory of Microwell Arrays Performing as Generators-Collectors Based on a Single Bipolar Plane Electrode
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基于单个双极平面电极的微孔阵列作为发生器-收集器的理论
DOI：
10.1002/celc.201500321
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发表时间：
2016-03-01
期刊：
影响因子：
4
通讯作者：
Amatore, Christian
中科院分区：
文献类型：
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作者：
Oleinick, Alexander;Yan, Jiawei;Amatore, Christian
我们之前曾报道过具有更高灵敏度和对干扰物虚拟免疫力的电分析微孔阵列。此类阵列设计为在经典的发生器-收集器模式下运行，但当其公共平面收集器浮动时也表现出类似的特性。这证明无偏集电极充当双极电极。在这项工作中，阐述了一种理论来详细研究这种现象的普遍性及其局限性。这表明，如果分析物属于具有相对较快电子速率常数的氧化还原对，则双极集电极的效率几乎与偏置时一样有效，从而抑制了分析应用对具有明显增益的双恒电位仪的需求。相反，如果电子转移的分析物速率常数很小，则双极模式下的有效操作仍然可行，但需要大幅降低阵列中的微孔密度。
Electroanalytical arrays of microwells with increased sensitivity and virtual immunity to interferents have been previously reported by us. Such arrays were designed to be operated in a classical generator-collector mode but exhibited also similar properties when their common planar collector was left floating. This evidenced that the unbiased collector acted as a bipolar electrode. In this work, a theory is elaborated to investigate in great detail the generality of this phenomenon and its limits. This establishes that if the analyte pertains to a redox couple with relatively fast electron rate constants, the bipolar collector results to be almost as efficient as when biased, thus suppressing the need for a bi-potentiostat with obvious gain for analytical applications. Conversely, if the analyte rate constant of electron transfer is small, efficient operation in a bipolar mode remains feasible but requires a drastic decrease of the microwell density in the array.