Functional and structural brain connectivity of young binge drinkers: a follow-up study
Functional and structural brain connectivity of young binge drinkers: a follow-up study
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DOI：
10.1038/srep31293
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发表时间：
2016-08-10
影响因子：
4.6
通讯作者：
Maestu, F.
中科院分区：
文献类型：
--
作者：
Correas, A.;Cuesta, P.;Maestu, F.
青春期是一个正在进行的大脑成熟期，其特征是功能和结构网络的分层变化。因此，年轻的大脑特别容易受到酒精的毒害。如今，酗酒是一种在青少年中日益普遍的饮酒模式。本研究的目的是评估年轻酗酒者两年来默认模式网络(DMN)的功能和解剖连接的演变。39名大学生(对照组22名，酗酒者17名)在两年的时间里进行了两次闭眼静息脑磁图和弥散张量成像(DTI)检查。小组比较表明，在保持狂饮模式至少两年后，与对照组相比，狂饮的人显示出DMN的大脑连接性增强。另一方面，无论是在群体之间还是在时间上，结构连通性都没有显示出显著的差异。这些发现指出，持续的酗酒模式会导致正常大脑成熟过程中的功能变化，甚至在解剖学变化可以被检测到之前。
Adolescence is a period of ongoing brain maturation characterized by hierarchical changes in the functional and structural networks. For this reason, the young brain is particularly vulnerable to the toxic effects of alcohol. Nowadays, binge drinking is a pattern of alcohol consumption increasingly prevalent among adolescents. The aim of the present study is to evaluate the evolution of the functional and anatomical connectivity of the Default Mode Network (DMN) in young binge drinkers along two years. Magnetoencephalography signal during eyes closed resting state as well as Diffusion Tensor Imaging (DTI) were acquired twice within a 2-year interval from 39 undergraduate students (22 controls, 17 binge drinkers) with neither personal nor family history of alcoholism. The group comparison showed that, after maintaining a binge drinking pattern along at least two years, binge drinkers displayed an increased brain connectivity of the DMN in comparison with the control group. On the other hand, the structural connectivity did not show significant differences neither between groups nor over the time. These findings point out that a continued pattern of binge drinking leads to functional alterations in the normal brain maturation process, even before anatomical changes can be detected.