Pregnancy-induced hypertension is associated with maternal history and a risk of cardiovascular disease in later life: A Japanese cross-sectional study
Pregnancy-induced hypertension is associated with maternal history and a risk of cardiovascular disease in later life: A Japanese cross-sectional study
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DOI：
10.1016/j.maturitas.2013.04.002
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发表时间：
2013-07-01
期刊：
影响因子：
4.9
通讯作者：
Hayashi, Kunihiko
中科院分区：
文献类型：
--
作者：
Kurabayashia, Takumi;Mizunuma, Hideki;Hayashi, Kunihiko
目的：阐明妊高征（PIH）与妊高征母婴遗传与日本妇女晚年心血管疾病风险之间的关系。研究设计：日本护士健康研究（JNHS）是一项关于日本女性健康的队列研究。从2001年到2007年的JNHS基线调查数据被用来进行横断面分析。在基线调查的49,927名受访者中，10,456名基线年龄为bb0 = 45岁的产妇被纳入分析。主要结局指标：母亲有PIH病史的女性PIH的年龄调整比值比（OR），以及高血压、高胆固醇血症和糖尿病（DM）参与者的年龄调整比值比（OR）。结果：母亲有PIH病史的妇女与母亲无PIH病史的妇女相比，经年龄调整的PIH OR为2.72（95%可信区间[CI]: 2.14-3.46）。经logistic回归分析确定，PIH是高血压（年龄校正OR: 2.85, 95% CI: 2.45-3.11）、高胆固醇血症（年龄校正OR: 1.49, 95% CI: 1.29-1.72）和糖尿病（年龄校正OR: 1.53, 95% CI: 1.11-2.11）的危险因素。结论：在日本女性中，母亲患有PIH的女性患PIH的风险大约是母亲没有患PIH的女性的2.7倍。PIH是晚年高血压、高胆固醇血症和糖尿病的危险因素。2013爱思唯尔爱尔兰有限公司版权所有。
Objective: To clarify the associations between pregnancy-induced hypertension (PIH) with heritability of PIH from mother to daughter and the risk of cardiovascular disease in later life in Japanese women.Study design: The Japan Nurses' Health Study (JNHS) is a cohort study of Japanese women's health. Data from the JNHS baseline survey between 2001 and 2007 were used to conduct a cross-sectional analysis. Of the 49,927 respondents in the baseline survey, 10,456 parous women who were >= 45 years old at baseline were included in the analysis.Main outcome measures: The age-adjusted odds ratio (OR) of PIH in women whose mother had a history of PIH, and the age-adjusted OR of PIH in participants for hypertension, hypercholesterolemia and diabetes mellitus (DM).Results: The age-adjusted OR of PIH was 2.72 (95% confidence interval [CI]: 2.14-3.46) in women whose mother had a history of PIH compared with those whose mother did not have PIH. PIH was a risk factor for hypertension (age adjusted OR: 2.85, 95% CI: 2.45-3.11), hypercholesterolemia (age-adjusted OR: 1.49, 95% CI: 1.29-1.72) and DM (age-adjusted OR: 1.53, 95% CI: 1.11-2.11), as determined by logistic regression analysis.Conclusions: In Japanese women, the risk of PIH is approximately 2.7-fold greater in those whose mothers also had PIH compared with those whose mothers did not. PIH is a risk factor for hypertension, hypercholesterolemia, and diabetes mellitus in later life. (C) 2013 Elsevier Ireland Ltd. All rights reserved.