STUDIES ON THE EFFECT OF DOPAMINE ON THE HUMAN PLATELET RESPONSE
STUDIES ON THE EFFECT OF DOPAMINE ON THE HUMAN PLATELET RESPONSE
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DOI：
10.1111/j.1440-1681.1992.tb00513.x
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发表时间：
1992-09-01
影响因子：
2.9
通讯作者：
TROVATI, M
中科院分区：
文献类型：
--
作者：
ANFOSSI, G;MASSUCCO, P;TROVATI, M
1.本研究探讨多巴胺对健康受试者血小板反应的体外影响.多巴胺浓度超过5 μ mol/L时，所有受试者均出现初级聚集反应和α-颗粒蛋白、β-血小板球蛋白和血小板因子-4的轻微释放。在25%的研究对象中，观察到多巴胺浓度超过100 μ mol/L的延迟二次聚集。低多巴胺浓度（5-7.5 nmol/L）增加了血小板对其他聚集剂（二磷酸腺苷、胶原蛋白和花生四烯酸钠）的敏感性。多巴胺可增强5-羟色胺亚聚集浓度的作用.低浓度的α-肾上腺素受体拮抗剂（酚妥拉明和育亨宾）可阻断多巴胺对血小板反应的影响;多巴胺受体拮抗剂（氟哌啶醇和多潘立酮）可降低多巴胺诱导的反应者继发性聚集波的程度，但不能阻止原发性聚集和对其他聚集剂的影响.目前的数据表明，多巴胺对人血小板的影响主要是通过与α-肾上腺素受体的相互作用介导的。
1. The present study investigated the in vitro effect of dopamine on platelet responses in healthy subjects.2. Dopamine concentrations over 5-mu-mol/L induced a primary aggregating response and a slight release of alpha-granule proteins, beta-thromboglobulin and platelet factor-4 in all subjects. In 25% of investigated subjects a delayed secondary aggregation was observed with dopamine concentrations over 100-mu-mol/ L.3. Low dopamine concentrations (5-7.5 nmol/L) increased the platelet sensitivity to other aggregating agents (adenosine diphosphate, collagen and sodium arachidonate). The effect of subaggregating concentrations of serotonin was potentiated by dopamine.4. The effect of dopamine on platelet responses was prevented by low concentrations of alpha-adrenoceptor antagonists (phentolamine and yohimbine); antagonists of dopamine receptors (haloperidol and domperidone) were able to decrease the extent of the dopamine-induced secondary aggregating wave in the responders, but they failed to prevent the primary aggregation and the effects on platelet response to other aggregating agents.5. The present data demonstrated that the effects of dopamine on human platelets are mainly mediated by interactions with alpha-adrenoceptors.