Follistatin-like 3 (FSTL3) Mediated Silencing of Transforming Growth Factor β (TGFβ) Signaling Is Essential for Testicular Aging and Regulating Testis Size
Follistatin-like 3 (FSTL3) Mediated Silencing of Transforming Growth Factor β (TGFβ) Signaling Is Essential for Testicular Aging and Regulating Testis Size
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DOI：
10.1210/en.2012-1886
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发表时间：
2013-03-01
期刊：
影响因子：
4.8
通讯作者：
Mukherjee, Abir
中科院分区：
文献类型：
--
作者：
Oldknow, Karla J.;Seebacher, Jan;Mukherjee, Abir
卵泡素样3 （Follistatin-like 3, FSTL3）是一种结合并抑制激活素等TGF β配体作用的糖蛋白。FSTL3和激活信号在器官发育和体内平衡中的作用尚不完全清楚。作者发现，缺乏FSTL3基因的小鼠睾丸明显增大，其与年龄相关的退化也被推迟。这些FSTL3基因敲除小鼠显示出支持细胞数量增加，允许精子发生增加，但在其他方面显示正常睾丸功能。数据显示，FSTL3缺失导致睾丸中AKT信号和SIRT1表达增加。这证明了TGF β配体和AKT信号之间的串扰，并导致了增加细胞存活和抗衰老的潜在机制。这些发现确定了FSTL3在限制睾丸器官大小和促进与年龄相关的睾丸退化中的关键作用。[中国医学杂志]，2013。
Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGF beta ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood. The authors show mice deficient in FSTL3 develop markedly enlarged testes that are also delayed in their age-related regression. These FSTL3 knockout mice exhibit increased Sertoli cell numbers, allowing for increased spermatogenesis but otherwise showing normal testicular function. The data show that FSTL3 deletion leads to increased AKT signaling and SIRT1 expression in the testis. This demonstrates a cross-talk between TGF beta ligand and AKT signaling and leads to a potential mechanism for increased cellular survival and antiaging. The findings identify crucial roles for FSTL3 in limiting testis organ size and promoting age-related testicular regression. (Endocrinology 154: 1310-1320, 2013)