Quality of life, functioning and cognition in bipolar disorder and major depression: A latent profile analysis
Quality of life, functioning and cognition in bipolar disorder and major depression: A latent profile analysis
复制标题
DOI：
10.1016/j.psychres.2016.04.102
复制
发表时间：
2016-07-30
影响因子：
11.3
通讯作者：
Fonseca, Rochele Paz
中科院分区：
文献类型：
--
作者：
Cotrena, Charles;Branco, Laura Damiani;Fonseca, Rochele Paz
本研究旨在确定抑郁症（MDD）、双相情感障碍（BD）和健康成人的功能和生活质量（QOL）概况，以及与这些概况相关的临床、人口统计学和认知变量。参与者完成WHODAS 2.0和WHOQOL-BREF，并提交潜在特征分析。四个集群解决方案最适合我们的数据。第一类主要由健康成人组成，具有最高的功能和生活质量。聚类2包含有亚临床抑郁症状和精神合并症的老年患者，他们的生活质量和功能障碍与情绪症状和几种认知能力有关。轻度至中度抑郁的MDD、BDI或BDII患者，如第3类患者，可能从认知灵活性、抑制、计划和持续注意力方面的干预中获益更显著。最后，有情绪障碍和临床显著抑郁水平的患者，以及有自杀企图史的患者，如第4类患者，可能会从针对工作记忆、抑制控制和认知灵活性的干预中受益；也就是三个核心的执行功能。这些发现应该进一步研究，并用于指导情绪障碍和不同类型功能障碍患者的治疗。2016爱思唯尔爱尔兰有限公司版权所有。
This study aimed to identify profiles of functioning and quality of life (QOL) in depression (MDD), bipolar disorder (BD) and healthy adults, as well as the clinical, demographic and cognitive variables associated with each of these profiles. Participants completed the WHODAS 2.0 and WHOQOL-BREF, which were submitted to latent profile analysis. The four cluster solution provided the best fit for our data. Cluster I consisted mostly of healthy adults, and had the highest functioning and QOL. Clusters 2 contained older patients with subclinical depressive symptoms and psychiatric comorbidities, whose impairments in QOL and functioning were associated with mood symptoms and several cognitive abilities. Patients with MDD, BDI or BDII with mild to moderate depression, such as those in cluster 3, may benefit more significantly from interventions in cognitive flexibility, inhibition, planning, and sustained attention. Lastly, patients with mood disorders and clinically significant levels of depression, as well as a history of suicide attempts, like those in cluster 4, may benefit from interventions aimed at working memory, inhibitory control, and cognitive flexibility; that is, the three core executive functions. These findings should be further investigated, and used to guide treatments for patients with mood disorders and different patterns of functional impairment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.