Clinical features and outcome in North American adults with idiopathic basal arterial occlusive disease without moyamoya collaterals.
Clinical features and outcome in North American adults with idiopathic basal arterial occlusive disease without moyamoya collaterals.
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DOI：
10.1227/01.neu.0000371977.55753.de
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发表时间：
2010-08
期刊：
影响因子：
4.8
通讯作者：
Derdeyn CP
中科院分区：
文献类型：
--
作者：
Goyal MS;Hallemeier CL;Zipfel GJ;Rich KM;Grubb RL Jr;Chicoine MR;Moran CJ;Cross DT 3rd;Dacey RG Jr;Derdeyn CP
To define the clinical characteristics and outcome of patients with idiopathic stenosis or occlusion of the basal arteries, without moyamoya collateral formation. We identified patients who presented to our institution from 1996 to 2005 with occlusive disease of the distal internal carotid artery or the proximal middle or anterior cerebral arteries demonstrated by digital subtraction cerebral angiography. We excluded those with evidence of atherosclerotic disease, systemic vasculitis, moyamoya phenomenon or any other condition that could otherwise explain their arterial occlusive disease. Medical records were reviewed for presenting symptoms and clinical characteristics. Outcome was determined from chart review and phone interviews. Twelve patients were identified. All presented with TIA or stroke. Eleven were women. Age at presentation ranged from 34 to 71 years. Nine had a history of hypertension. Five had unilateral intracranial disease. None of the five developed recurrent stroke on medical therapy during an average follow up of 29 months. Seven had bilateral disease. Ischemic stroke occurred between 2 and 107 months after the initial event in five of eight medically-treated hemispheres. One patient developed moyamoya collaterals on follow up angiography. The clinical features and outcome of these patients are similar to those reported in large case series of North American patients with moyamoya phenomenon. These data suggest a common etiology for the basal arterial occlusive process and a variable ability to form moyamoya collaterals.
