Differential effects of ethanol in adolescent and adult rats
Differential effects of ethanol in adolescent and adult rats
复制标题
DOI：
10.1111/j.1530-0277.1996.tb01133.x
复制
发表时间：
1996-11-01
影响因子：
3.2
通讯作者：
Swartzwelder, HS
中科院分区：
文献类型：
--
作者：
Little, PJ;Kuhn, CM;Swartzwelder, HS
酒精在儿童和青少年中的使用是普遍的，然而，很少有人知道酒精暴露在这一时期的产后发育的影响。本研究的目的是比较青春期前和成年大鼠对酒精镇静作用的相对敏感性。用4或5 g/kg乙醇处理后，20和30日龄大鼠的翻正反射明显早于60日龄大鼠。30日龄大鼠翻正反射恢复时的血清乙醇浓度（SEC）显著高于60日龄大鼠，乙醇对自发活动的影响也存在发育差异。60日龄大鼠2.5g/kg乙醇普遍降低自发活动。乙醇并没有显着改变自发活动在20日龄和30日龄的大鼠，最后，有显着的发展差异，乙醇的药代动力学与显着延迟的时间达到峰值SEC在60日龄的大鼠相对于20日龄和30日龄的大鼠。这些研究结果表明，青春期大鼠对乙醇的镇静作用不太敏感，因为它们恢复翻正反射的时间比成年大鼠更早，SECs也更高。
Alcohol use in children and adolescents is widespread, However, very little is known about the effects of alcohol exposure during this period of postnatal development. The goal of the present study was to compare the relative sensitivity to the sedative effects of alcohol in periadolescent and adult rats. After treatment with either 4 or 5 g/kg ethanol, both 20- and 30-day-old rats regained their righting reflex significantly earlier than 60-day old rats. In 30-day-old rats, serum ethanol concentrations (SECs) were significantly greater at the time of the recovery of the righting reflex than 60-day-old rats, Developmental differences in the effects of ethanol on locomotor activity were also observed, In 60-day-old rats, 2.5 g/kg ethanol generally decreased locomotor activity. Ethanol did not significantly alter locomotor activity in 20- and 30-day-old rats, Finally, there were significant developmental differences in the pharmacokinetics of ethanol with a significant delay in the time to peak SECs in 60-day-old rats relative to 20- and 30-day-old rats. These findings indicate that periadolescent rats are less sensitive to the sedative effects of ethanol as they recovered their righting reflex earlier and at significantly higher SECs than adult rats.