Gender differences in glucose kinetics and substrate oxidation during exercise near the lactate threshold.
Gender differences in glucose kinetics and substrate oxidation during exercise near the lactate threshold.
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在接近乳酸阈值的运动过程中，葡萄糖动力学和底物氧化存在性别差异。
DOI：
10.1152/japplphysiol.00296.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Zderic,TedW
中科院分区：
文献类型：
--
作者：
Ruby,BrentC;Coggan,AndrewR;Zderic,TedW
本研究的目的是确定男性和女性在运动过程中相对于乳酸阈值（LT）的血糖动力学和底物氧化。受试者在LT（分别为70%和90% LT）时以70%和90%的O2摄取量（V steco 2）骑自行车25分钟。用预充的[6，6 - 2 H]葡萄糖恒定输注测定血浆葡萄糖出现（Ra）和消失（Rd）。男性[70%和90% LT时的去脂质量（FFM）−1· min − 1分别为22.6 ± 1.9和39.9 ± 3.9 μmol · kg −1· min− 1]和女性[70%和90% LT时的FFM−1·min− 1分别为22.3 ± 2.7和33.9 ± 5.7 μmol · kg −1· min− 1]之间的葡萄糖Rabe无显著差异。同样，男性（70%和90% LT分别为21.2 ± 1.9和38.1 ± 3.7 μmol · kg FFM−1· min− 1）和女性（70%和90% LT分别为21.3 ± 2.8和33.3 ± 5.6 μmol · kg FFM−1· min− 1）之间的葡萄糖Rd也无显著差异。虽然在碳水化合物（CHO）对总能量消耗的相对贡献方面没有性别差异，但肌糖原对总CHO氧化的相对贡献（70% LT时，男性和女性分别为75.8 ± 3.2和64.2 ± 8.0%，男性和女性分别为75.1 ± 2.6和60.1 ± 11.2%，在90% LT）中女性较低。因此，血糖对总CHO氧化的相对贡献在女性中显著更高。这些结果表明，尽管男性和女性的血浆葡萄糖Ra和R d相似，但相对于LT，在中等强度运动期间，女性的肌糖原和血糖的相对贡献显著不同。
The purpose of this investigation was to determine plasma glucose kinetics and substrate oxidation in men and women during exercise relative to the lactate threshold (LT). Subjects cycled for 25 min at 70 and 90% of O2uptake (V˙o2) at LT (70 and 90% LT, respectively). Plasma glucose appearance (Ra) and disappearance (Rd) were determined with a primed constant infusion of [6,6-2H]glucose. There were no significant differences in glucose Rabetween men [22.6 ± 1.9 and 39.9 ± 3.9 μmol · kg fat-free mass (FFM)−1· min−1for 70 and 90% LT, respectively] and women (22.3 ± 2.7 and 33.9 ± 5.7 μmol · kg FFM−1· min−1for 70 and 90% LT, respectively). Similarly, there were no significant differences in glucose Rdbetween men (21.2 ± 1.9 and 38.1 ± 3.7 μmol · kg FFM−1· min−1for 70 and 90% LT, respectively) and women (21.3 ± 2.8 and 33.3 ± 5.6 μmol · kg FFM−1· min−1for 70 and 90% LT, respectively). Although there were no differences between genders in the relative contribution of carbohydrate (CHO) to total energy expenditure, the relative contribution of muscle glycogen to total CHO oxidation (75.8 ± 3.2 and 64.2 ± 8.0% for men and women, respectively, at 70% LT and 75.1 ± 2.6 and 60.1 ± 11.2% for men and women, respectively, at 90% LT) was lower in women. Consequently, the relative contribution of blood glucose to total CHO oxidation was significantly higher in women. These results indicate that although plasma glucose Raand Rdare similar in men and women, the relative contribution of muscle glycogen and blood glucose is significantly different in women during moderate-intensity exercise relative to LT.
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