Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens
Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens
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DOI：
10.1309/ajcpk1zc9wnhccmu
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发表时间：
2012-08-01
影响因子：
3.5
通讯作者：
Lin, Fan
中科院分区：
文献类型：
--
作者：
Timek, Dana T.;Shi, Jianhui;Lin, Fan
肝转移与肝细胞癌（HCC）的区别可能是一个诊断挑战。精氨酸酶-1（Arginase-1，Arg-1）是近年来发现的肝癌标志物。对1，240例手术标本和62例肝脏细针穿刺标本（29例HCC，28例转移性肿瘤和5例良性肝脏病例）进行了Arg-1，肝细胞石蜡-1（HepPar-1）和磷脂酰肌醇蛋白聚糖-3表达的免疫组织化学评价。组织芯片切片的染色结果显示，2.7%和3.1%的非肝肿瘤病例分别为HepPar-1和磷脂酰肌醇蛋白聚糖-3阳性，没有一个为Arg-1阳性。细针穿刺标本中，19例HCC对所有3种标志物均呈阳性; 9例对1种或2种标志物呈阳性;仅1例对所有3种标志物均呈阴性。这些数据表明，Arg-1是区分非HCC与HCC的最特异性标志物。建议使用3个标志物作为区分HCC与转移癌的一组标志物。
Distinction of liver metastases from hepatocellular carcinoma (HCC) may present a diagnostic challenge. Arginase-1 (Arg-1) is a marker for HCC recently described in some literature. Immunohistochemical evaluation of Arg-1, hepatocyte paraffin-1 (HepPar-1), and glypican-3 expression was performed on 1,240 surgical specimens and 62 liver fine-needle aspiration specimens (29 HCCs, 28 metastatic tumors, and 5 benign liver cases). The staining results on tissue microarray sections showed that 2.7% and 3.1% of nonhepatic tumor cases were positive for HepPar-1 and glypican-3, respectively; none was positive for Arg-1. For fine-needle aspiration specimens, 19 HCCs were positive for all 3 markers; 9 were positive for 1 or 2 markers; and only I case was negative for all 3 markers. These data demonstrate that Arg-1 is the most specific marker in differentiating a non-HCC from HCC. It is recommended to use 3 markers as a panel in distinguishing HCC from metastatic carcinoma.