Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women
Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women
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DOI：
10.1210/jc.2003-032229
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发表时间：
2004-07-01
影响因子：
5.8
通讯作者：
Ylikorkala, O
中科院分区：
文献类型：
--
作者：
Nikander, E;Tiitinen, A;Ylikorkala, O
亚洲女性的心血管风险低被认为是由于高维生素B2摄入量。在一项双盲、随机、安慰剂对照试验中，我们在56名有乳腺癌病史的非糖尿病绝经后妇女中研究了单独的阿托伐他汀（114 mg/d）对血脂、脂蛋白、胰岛素敏感性和生长激素释放肽的影响。给予异黄酮或安慰剂片剂3个月，两种治疗方案在2个月的洗脱期后交叉。总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇、甘油三酯、载脂蛋白B和A1以及脂蛋白（a）的浓度不受异黄酮的影响。然而，在安慰剂治疗期间，低密度脂蛋白胆固醇水平高于中位数4.20 mmol/L的女性显示出升高[0.65 +/- 0.60（SD）mmol/L]，这与安慰剂治疗期间的下降有统计学差异（-0.45 +/-0.67 mmol/L，P = 0.009）。通过口服2小时葡萄糖耐量试验（75 g）评估，异黄酮不影响胰岛素敏感性。Ghrelin水平的变化在安慰剂组（+ 47.9 +/- 198 mumol/L）和单抗组（-7.1 +/- 151 mumol/L）之间存在差异（P = 0.048）。总之，我们发现单抗对绝经后妇女的血脂、脂蛋白或胰岛素敏感性没有影响，这意味着对血管没有益处。异黄酮可以降低胃饥饿素水平，从而减少饥饿感和体重。
The low cardiovascular risk in Asian women has been thought to result from high isoflavonoid intake. In a double-blind, randomized, placebo-controlled trial, we studied the effects of isolated isoflavonoids ( 114 mg/d) on lipids, lipoproteins, insulin sensitivity, and ghrelin in 56 nondiabetic postmenopausal women with a history of breast cancer. Isoflavonoid or placebo tablets were given for 3 months, and the treatment regimens crossed over after a 2-month washout period.The concentrations of total cholesterol, high- and low-density lipoprotein cholesterol, triglycerides, apolipoproteins B and A1, and lipoprotein ( a) were not affected by isoflavonoids. However, during the isoflavonoid regimen, women with low-density lipoprotein cholesterol level above the median 4.20 mmol/liter) showed a rise [0.65 +/- 0.60 (SD) mmol/ liter], which was statistically different from the fall during the placebo regimen ( - 0.45 +/- 0.67 mmol/ liter, P = 0.009).Isoflavonoids did not affect insulin sensitivity as assessed by an oral 2-h glucose tolerance test ( 75 g). Changes in ghrelin levels differed ( P = 0.048) during the isoflavonoid ( - 7.1 +/- 151 mumol/liter) and placebo regimens ( + 47.9 +/- 198 mumol/liter).In conclusion, we found no effects of isolated isoflavonoids on lipids, lipoproteins, or insulin sensitivity in postmenopausal women, implying no vascular benefit. Isoflavonoids may reduce ghrelin levels and thus hunger and weight.