Recent trends in prostate cancer incidence and mortality in Southeast England
Recent trends in prostate cancer incidence and mortality in Southeast England
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DOI：
10.1016/s0302-2838(03)00085-x
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发表时间：
2003-04-01
期刊：
影响因子：
23.4
通讯作者：
Moller, H
中科院分区：
文献类型：
--
作者：
Evans, HS;Moller, H
目的：为了调查前列腺癌的发病率和死亡率的最新趋势，特别是参考诊断技术和treatment.Methods的变化：泰晤士癌症登记处被用来确定所有的男人，居住在英格兰东南部，1990年和1999年之间诊断为前列腺癌。有关前列腺癌死亡率的信息来自国家统计局。其他数据来源被用来确定在东南英格兰进行的前列腺经尿道切除术（TURP）和开放性前列腺切除术的数量，以及为治疗良性前列腺增生症（BPH）而发出的处方数量。结果：从1990年开始，前列腺癌的年龄标准化发病率稳步上升，然后在1996年开始趋于平稳。这一增加完全限于局限性肿瘤;非局限性肿瘤在此期间呈轻微下降趋势。标准化死亡率保持不变，1997年略有下降，与发病率的下降相对应。前列腺增生症的药物治疗增加了，相应减少TURPs.Conclusion的数量：前列腺癌发生的变化完全是由于局部病例的发病率变化。非局部病例的发生率和死亡率几乎保持不变。局限性前列腺癌发病率的增加趋势可能主要是由于通过增加使用前列腺特异性抗原（PSA）检测，然后进行前列腺根治性切除术，从而增加了检测。PSA检测和BPH药物治疗的综合效果是近年来局部病例的发病率水平稳定。(C)2003 Elsevier Science B. V.保留所有权利。
Objective: To investigate recent trends in prostate cancer incidence and mortality, with particular reference to changes in diagnostic techniques and treatment.Methods: The Thames Cancer Registry was used to identify all men, resident in SE England, diagnosed with prostate cancer between 1990 and 1999. Information regarding prostate cancer mortality was obtained from the Office of National Statistics. Other data sources were used to ascertain the number of transurethral resections of the prostate (TURP) and open prostatectomies performed in SE England, and the number of prescriptions issued for the treatment of benign prostatic hyperplasia (BPH).Results: There was a steady increase in the age-standardised incidence of prostate cancer from 1990, which then began to plateau in 1996. The increase was entirely restricted to localised tumours; non-localised tumours showed a slight downward trend over this period. Age-standardised mortality rates have remained constant, with a slight fall in 1997 corresponding to the decline in incidence rates. Medical treatment for BPH has increased, with a corresponding reduction in the number of TURPs.Conclusion: The change in occurrence of prostate cancer is entirely due to changes in the incidence of localised cases. Incidence of non-localised cases and mortality remained almost constant. The increasing tendency in incidence of localised prostate cancer is likely to be principally due to increased detection, through increased use of prostate-specific antigen (PSA) testing followed by radical resections of the prostate. The aggregate effect of PSA testing and medical treatment of BPH is a stabilisation in the incidence level of localised cases in recent years. (C) 2003 Elsevier Science B.V. All rights reserved.