Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS
Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS
复制标题
DOI：
10.1016/j.schres.2004.09.009
复制
发表时间：
2004-12-15
影响因子：
4.5
通讯作者：
Heaton, RK
中科院分区：
文献类型：
--
作者：
Green, MF;Kern, RS;Heaton, RK
人们普遍认为，精神分裂症患者的认知缺陷与功能结局有关。然而，对认知和功能结果之间的纵向关系的支持还没有得到很好的记录。本文综述了最近发表的18篇关于精神分裂症认知与社区结局之间关系的纵向研究(至少6个月随访)。这些研究的结果显示，相当多的支持精神分裂症认知和社区结果之间的纵向联系。这些研究表明，认知评估可以预测以后的功能结果，并为精神分裂症认知缺陷的精神药理学干预提供了理论基础。尽管认知与社区结果之间的关系得到了很好的支持，但很明显，除了认知之外，社区功能还受到许多因素的影响，这些因素通常在临床试验研究中不被考虑(例如，心理社会康复和教育/职业机会)。在论文的第二部分，我们考虑了认知绩效测量和社区结果之间的干预步骤。这些步骤往往对精神分裂症认知增强剂的临床试验具有重要意义。(C)2004爱思唯尔B.V.保留所有权利。
It is generally accepted that cognitive deficits in schizophrenia are related to functional outcome. However, support for longitudinal relationships between cognition and functional outcome has not been as well documented. The current paper presents a review of 18 recently published longitudinal studies (minimum 6-month follow up) of the relationships between cognition and community outcome in schizophrenia. Results from these studies reveal considerable support for longitudinal associations between cognition and community outcome in schizophrenia. These studies demonstrate that cognitive assessment predict later functional outcome and provide a rationale for psychopharmacological interventions for cognitive deficits in schizophrenia. Although the relationships between cognition and community outcome are well-supported, it is clear that community functioning is also affected by a host of factors apart from cognition that are usually not considered in clinical trial studies (e.g., psychosocial rehabilitation and educational/vocational opportunities). In the second part of the paper, we consider intervening steps between cognitive performance measures and community outcome. These steps are apt to have important implications for clinical trials of cognition-enhancing agents in schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.