Seroprevalence of Helicobacter pylori among Egyptian newborns and their mothers:: A preliminary report
Seroprevalence of Helicobacter pylori among Egyptian newborns and their mothers:: A preliminary report
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DOI：
10.4269/ajtmh.1999.61.37
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发表时间：
1999-07-01
影响因子：
3.3
通讯作者：
Clemens, J
中科院分区：
文献类型：
--
作者：
Bassily, S;Frenck, RW;Clemens, J
幽门螺杆菌是世界上最常见的人类细菌感染之一，发展中国家的儿童在幼年就感染了幽门螺杆菌。我们前瞻性地评估了一组孕妇及其后代中幽门螺杆菌血清抗体的流行率。母亲在妊娠晚期采集血清，子代在7-9个月和18个月龄时采集血清。用市售的Hp-Stat(TM)试剂盒检测受试者血清中的Hp抗体。169名母亲的血清可用于检测，其中88%的样本抗-H。幽门螺杆菌免疫球蛋白。在接受检测的169名儿童中，13%的7-9个月大的婴儿和25%的18个月大的儿童有幽门螺杆菌感染的血清学证据。这些数据表明，感染幽门螺杆菌在埃及很常见，感染发生在非常年轻的年龄。
Helicobacter pylori is one of the most common human bacterial infections in the world and children in the developing countries acquire H. pylori infection early in life. We prospectively evaluated the prevalence of serum antibodies to H. pylori in a cohort of pregnant women and their offspring. Mothers' sera were collected during the third trimester of pregnancy and sera from their offspring were collected when they were 7-9 months and 18 months of age. Pylori-Stat(TM), a commercially available ELISA kit, was used to detect antibodies to H. pylori in the serum of the subjects tested. Sera from 169 mothers were available for testing and 88% of these samples were positive for anti-H. pylori IgG. Of the 169 children tested, 13% of the infants 7-9 months of age and 25% of the children 18 months of age had serologic evidence of H. pylori infection. These data indicate that infection with N. pylori is common in Egypt and acquisition of infection occurs at a very young age.