Postpartum intravenous dexamethasone for severely preeclamptic patients without hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome: A randomized trial
Postpartum intravenous dexamethasone for severely preeclamptic patients without hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome: A randomized trial
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DOI：
10.1097/01.aog.0000154887.57440.d1
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发表时间：
2005-04-01
影响因子：
7.2
通讯作者：
May, WL
中科院分区：
文献类型：
--
作者：
Barrilleaux, PS;Martin, JN;May, WL
目的：我们比较了产妇的严重先兆子痫的患者谁是产后管理或不连续静脉注射dexamethas.METHODS：这项研究是一项随机，盲安慰剂对照临床试验比较使用地塞米松产后（10 mg-10 mg-5 mg-5 mg静脉注射每12小时）与盐水对照严重先兆子痫患者。Student t和卡方检验用于数据分析，P <0.05被认为是显著的。结果：来自2000-2003年期间接受治疗的157名患者（77名患者接受地塞米松治疗，80名患者接受安慰剂治疗）的数据进行了分析，两组之间的人口统计学、诊断标准、基线实验室值和产后结果相似。虽然地塞米松治疗组患者因未控制的高血压而返回分娩/分娩/恢复室的比例（6.5%比11.3%）低于对照组患者，但在血压、抗高血压药物需求、实验室检查值、住院时间、产后48小时尿量或主要孕产妇发病率方面无显著差异。两个对照组患者发生溶血，肝酶升高，低血小板syndrome.CONCLUSION：辅助使用静脉注射地塞米松产后重度子痫前期患者不降低疾病的严重程度或持续时间。
OBJECTIVE: We compared maternal outcomes for patients with severe preeclampsia who were managed postpartum with or without adjunctive intravenous dexamethasone.METHODS: This study was a randomized, blinded placebo-controlled clinical trial comparing the use of dexamethasone postpartum (10 mg-10 mg-5 mg-5 mg intravenously every 12 hours) with a saline control in patients with severe preeclampsia. The Student t and chi(2) tests were used for data analysis, with P < .05 considered significant.RESULTS: Data from 157 patients (77 patients receiving dexamethasone, 80 patients receiving placebo) who were treated-during 2000-2003 were analyzed-Demographics, diagnostic criteria, baseline laboratory values, and postpartum outcomes were similar between groups. Although dexamethasone-treated patients had fewer returns (6.5% compared with 11.3%) to the labor/delivery/recovery unit for uncontrolled hypertension than control patients, no significant differences were found in blood pressure, antihypertensive requirements, laboratory values, length of hospitalization, interval urine output at 48 hours postpartum, or major maternal morbidity. Two control patients developed hemolysis, elevated liver enzymes, low platelets syndrome.CONCLUSION: Adjunctive use of intravenous dexamethasone for postpartum patients with severe preeclampsia does not reduce disease severity or duration.