Spinal Cord Injury Disrupts Resting-State Networks in the Human Brain
Spinal Cord Injury Disrupts Resting-State Networks in the Human Brain
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DOI：
10.1089/neu.2017.5212
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发表时间：
2018-01-11
影响因子：
4.2
通讯作者：
Ray, Wilson Z.
中科院分区：
文献类型：
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作者：
Hawasli, Ammar H.;Rutlin, Jerrel;Ray, Wilson Z.
尽管美国有253,000名脊髓损伤（SCI）患者，但人们对SCI如何影响大脑网络知之甚少。脊柱MRI只能提供结构信息，而不能洞察功能连接。静息状态功能MRI （RS-fMRI）通过识别静息状态网络（rsn）来量化网络连通性，并允许检测疾病期间功能相关的变化。鉴于脊髓传入大脑的强大网络，我们假设脊髓损伤会产生有意义的脑rsn变化。对10SCI受试者进行rs - fmri和功能评估。获得血氧依赖RS-fMRI序列。使用五种rsn进行基于种子的相关映射：默认模式（DMN）、背侧注意（DAN）、显著性（SAL）、控制（CON）和躯体运动（SMN）。采用错误发现率校正的双方法t检验比较正常对照受试者的rsn。脊髓损伤降低了SAL、SMN和DMN内的脑网络连接，并破坏了CON和SMN之间的反相关连接。当被分成单独的队列时，完全性而非完全性脊髓损伤破坏了SAL、DAN、SMN和DMN之间以及CON和SMN之间的连通性。最后，脊髓损伤后的连通性随着时间的推移而改变：初级运动皮层与初级体感皮层的连通性降低，视觉皮层与初级运动皮层的连通性降低，视觉皮层与感觉顶叶皮层的连通性降低。这些独特的发现表明，由于脊髓损伤，大脑中出现了功能网络的可塑性。脊髓损伤后的连通性变化可以作为预测脊髓损伤后功能恢复的生物标志物，并指导未来的治疗。
Despite 253,000 spinal cord injury (SCI) patients in the United States, little is known about how SCI affects brain networks. Spinal MRI provides only structural information with no insight into functional connectivity. Resting-state functional MRI (RS-fMRI) quantifies network connectivity through the identification of resting-state networks (RSNs) and allows detection of functionally relevant changes during disease. Given the robust network of spinal cord afferents to the brain, we hypothesized that SCI produces meaningful changes in brain RSNs. RS-fMRIs and functional assessments were performed on 10SCI subjects. Blood oxygen-dependent RS-fMRI sequences were acquired. Seed-based correlation mapping was performed using five RSNs: default-mode (DMN), dorsal-attention (DAN), salience (SAL), control (CON), and somatomotor (SMN). RSNs were compared with normal control subjects using false-discovery rate-corrected two way t tests. SCI reduced brain network connectivity within the SAL, SMN, and DMN and disrupted anti-correlated connectivity between CON and SMN. When divided into separate cohorts, complete but not incomplete SCI disrupted connectivity within SAL, DAN, SMN and DMN and between CON and SMN. Finally, connectivity changed over time after SCI: the primary motor cortex decreased connectivity with the primary somatosensory cortex, the visual cortex decreased connectivity with the primary motor cortex, and the visual cortex decreased connectivity with the sensory parietal cortex. These unique findings demonstrate the functional network plasticity that occurs in the brain as a result of injury to the spinal cord. Connectivity changes after SCI may serve as biomarkers to predict functional recovery following an SCI and guide future therapy.