Correlation of a scanning laser derived oedema index and visual function following grid laser treatment for diabetic macular oedema
Correlation of a scanning laser derived oedema index and visual function following grid laser treatment for diabetic macular oedema
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DOI：
10.1136/bjo.87.4.455
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发表时间：
2003-04-01
影响因子：
4.1
通讯作者：
McLeod, D
中科院分区：
文献类型：
--
作者：
Hudson, C;Flanagan, JG;McLeod, D
目的：相关的水肿指数的变化，通过扫描激光断层扫描与患者接受网格激光光凝治疗的临床显着的糖尿病黄斑水肿（DMO）的视功能的变化。方法：样本包括24例糖尿病患者视网膜增厚内500 pm的中心凹。入选标准包括logMAR视力为0.25或更好。在单次网格激光治疗前和治疗后1周内以及治疗后1、2、4和12周对患者进行两次评估。在每次访视时，患者接受logMAR视力、常规和短波长自动视野检查（SWAP）和扫描激光断层扫描。各视功能参数与平均水肿指数相关。平均水肿指数表示z分布信号宽度除以最大反射强度（任意单位）。Pearson相关系数（Bonferroni校正）进行的数据集上的每个patients.Results：13例患者表现出显着的相关性的平均水肿指数和至少一个测量的视觉功能为10度× 10度的扫描野，而10例患者相关的20度× 20度的扫描野。7例患者证明了两种扫描场的相关性。激光光凝通常导致周边敏感性立即丧失，而水肿指数在数周内发生变化。局部水肿并没有影响视力或字母的对比敏感度时，位于extraveally.Conclusions：相关的水肿指数的变化和视觉功能的网格激光光凝后，没有发现在所有患者。相关性的缺乏可以解释的局部分布的DMO在这个样本的患者，以及在水肿指数和视觉功能的变化的时间过程中的差异。该研究客观地记录了网格激光治疗后DMO的大小和分布的变化，并建立了这种变化与视功能变化的关系。
Aim: To correlate change of an oedema index derived by scanning laser tomography with change of visual function in patients undergoing grid laser photocoagulation for clinically significant diabetic macular oedema (DMO).Methods: The sample comprised 24 diabetic patients with retinal thickening within 500 pm of the fovea. Inclusion criteria included a logMAR visual acuity of 0.25, or better. Patients were assessed twice before a single session of grid laser treatment and within 1 week of, and at 1, 2, 4, and 12 weeks after, treatment. At each visit, patients underwent logMAR visual acuity, conventional and short wavelength automated perimetry (SWAP), and scanning laser tomography. Each visual function parameter was correlated with the mean oedema index. The mean oedema index represented the z-profile signal width divided by the maximum reflectance intensity (arbitrary units). A Pearson correlation coefficient (Bonferroni corrected) was undertaken on the data set of each patient.Results: 13 patients exhibited significant correlation of the mean oedema index and at least one measure of visual function for the 10degrees x 10degrees scan field while 10 patients correlated for the 20degrees x 20degrees scan field. Seven patients demonstrated correlation for both scan fields. Laser photocoagulation typically resulted in an immediate loss of perimetric sensitivity whereas the oedema index changed over a period of weeks. Localised oedema did not impact upon visual acuity or letter contrast sensitivity when situated extrafoveally.Conclusions: Correlation of change of the oedema index and of visual function following grid laser photocoagulation was not found in all patients. An absence of correlation can be explained by the localised distribution of DMO in this sample of patients, as well as by differences in the time course of change of the oedema index and visual function. The study has objectively documented change in the magnitude and distribution of DMO following grid laser treatment and has established the relation of this change to the change in visual function.