Fusaricidins B, C and D, new depsipeptide antibiotics produced by Bacillus polymyxa KT-8: Isolation, structure elucidation and biological activity
Fusaricidins B, C and D, new depsipeptide antibiotics produced by Bacillus polymyxa KT-8: Isolation, structure elucidation and biological activity
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DOI：
10.7164/antibiotics.50.220
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发表时间：
1997-03-01
影响因子：
3.3
通讯作者：
Kaneda, M
中科院分区：
文献类型：
--
作者：
Kajimura, Y;Kaneda, M
从由尖孢镰刀菌（Fusarium oxysporum）引起的大蒜基腐病的根际分离得到的多粘芽孢杆菌（Bacillus polymyxa）KT-8的培养液中，分离到少量的新缩肽类抗生素杀镰孢菌素（Fusaricidins）B、C和D。杀镰孢菌素B的结构主要通过各种NMR实验结合与杀镰孢菌素A（其结构先前已报道的复合物的主要组分）相关的氨基酸分析来阐明。由杀镰孢菌素C和D组成的级分未能成功分离，分别得到两者的约4：1混合物。杀镰孢菌素C和D的结构已确定的混合物内的详细分析的2D NMR谱。杀镰孢菌素B、C和D对真菌和革兰氏阳性菌的活性几乎与杀镰孢菌素A一样。
Fusaricidins B, C and D, new depsipeptide antibiotics, have been isolated as minor components from the culture broth of Bacillus polymyxa KT-8 which was obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. The structure of fusaricidin B has been elucidated mainly by various NMR experiments coupled with amino acid analysis in relation to fusaricidin A, the main component of the complex, whose structure was reported previously. The fraction consisting of fusaricidins C and D was unsuccessfully separated, giving roughly a 4:1 mixture of the two, respectively. The structures of fusaricidins C and D have been determined within the mixture by detailed analyses of the 2D NMR spectra. Fusaricidins B, C and D are active against fungi and Gram-positive bacteria almost as well as fusaricidin A.