Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis
Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis
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DOI：
10.1177/1352458512459289
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发表时间：
2013-04-01
影响因子：
5.8
通讯作者：
Zivadinov, Robert
中科院分区：
文献类型：
--
作者：
Hagemeier, Jesper;Yeh, E. Ann;Zivadinov, Robert
目的：研究青少年多发性硬化症(MS)和其他神经系统疾病(OND)患者及健康对照组(HC)皮质下深部灰质(SDGM)磁化率加权成像(SWI)滤波相的铁含量异常时相值。方法：用3T GE扫描仪对20例青少年MS、8例青少年OND患者和21例年龄性别匹配的HC进行扫描。结果：异常时相组织平均时相(MP-APT)显著增加(28.2%，P<0.01)，正常时相组织体积(NPTV)显著增加(P<0.05)。
Objective: The objective of this paper is to assess abnormal phase values, indicative of increased iron content, using susceptibility-weighted imaging (SWI)-filtered phase of the subcortical deep gray matter (SDGM) in adolescent multiple sclerosis (MS) and other neurological disorders (OND) patients, and in healthy controls (HC).Methods: Twenty adolescent MS and eight adolescent OND patients and 21 age-and sex-matched HC were scanned on a 3T GE scanner. Mean phase of abnormal phase tissue (MP-APT), MP-APT volume, normal phase tissue volume (NPTV) and normalized volume measurements were obtained for total SDGM, as well as specific structures separately.Results: Significantly increased MP-APT (28.2%, p