Live attenuated pre-erythrocytic malaria vaccines
Live attenuated pre-erythrocytic malaria vaccines
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DOI：
10.4161/21645515.2014.972764
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发表时间：
2014-10-01
影响因子：
4.8
通讯作者：
Wang, Ruobing
中科院分区：
文献类型：
--
作者：
Keitany, Gladys J.;Vignali, Marissa;Wang, Ruobing
尽管最近的控制措施已显着减少了许多流行地区的疟疾病例和死亡，但有效的疫苗对于根除这种寄生虫病至关重要。迄今为止开发的疟疾疫苗策略侧重于人类宿主和蚊媒中寄生虫复杂生命周期的不同阶段，包括基于亚单位的疫苗和全寄生虫疫苗。本综述重点关注迄今为止已在人体中进行测试的 3 种减毒活疟疾疫苗接种策略，并讨论了它们的进展、挑战以及已确定的保护的免疫相关性。
Although recent control measures have significantly reduced malaria cases and deaths in many endemic areas, an effective vaccine will be essential to eradicate this parasitic disease. Malaria vaccine strategies developed to date focus on different phases of the parasite's complex life cycle in the human host and mosquito vector, and include both subunit-based and whole-parasite vaccines. This review focuses on the 3 live-attenuated malaria vaccination strategies that have been tested in humans to date, and discusses their progress, challenges and the immune correlates of protection that have been identified.