A Macrocyclic Ruthenium Carbene for Size-Selective Alkene Metathesis
A Macrocyclic Ruthenium Carbene for Size-Selective Alkene Metathesis
复制标题
用于尺寸选择性烯烃复分解的大环钌卡宾
DOI：
10.1021/jacs.0c00081
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发表时间：
2020
影响因子：
15
通讯作者：
Diver, ST.
中科院分区：
文献类型：
--
作者：
Zhang, Y;Diver, ST.
报道了一种用于选择性交叉烯烃复分解反应的大环钌卡宾催化剂的合成。该催化剂对不同类型的1型烯烃均二聚反应表现出不同的反应活性，这与烯丙基取代基的聚集体大小有关。改变的反应特性允许在两种不同的1型烯烃和丙烯酸叔丁酯之间的竞争交叉烯烃复分解中选择性地形成产物。在这些反应中的选择性归因于大环催化剂的能力，以区分烯烃的基础上，他们的大小。还提供了用大环催化剂进行交叉复分解的两个制备实例。
The synthesis of a macrocyclic Ru carbene catalyst for selective cross alkene metathesis is reported. The new catalyst showed different reactivity for various type 1 alkenes in homodimerization which correlated with the aggregrate size of the allylic substituent. The altered reactivity profile allowed for selective product formation in competition cross alkene metathesis between two different type 1 alkenes andtert-butyl acrylate. Selectivity in these reactions is attributed to the ability of the macrocyclic catalyst to differentiate alkenes based on their size. Two preparative examples of cross metathesis with the macrocyclic catalyst are also provided.