Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer
Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer
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DOI：
10.1080/07357907.2019.1661427
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发表时间：
2019-09
影响因子：
2.4
通讯作者：
S. Yoshida;Zensho Ito;M. Suka;Tsuuse Bito;Shi-feng Kan;Takafumi Akasu;M. Saruta;M. Okamoto;Hiroaki Kitamura;S. Fujioka;T. Misawa;T. Akiba;Hiroyuki Yanagisawa;H. Sugiyama;S. Koido
中科院分区：
文献类型：
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作者：
S. Yoshida;Zensho Ito;M. Suka;Tsuuse Bito;Shi-feng Kan;Takafumi Akasu;M. Saruta;M. Okamoto;Hiroaki Kitamura;S. Fujioka;T. Misawa;T. Akiba;Hiroyuki Yanagisawa;H. Sugiyama;S. Koido
摘要探讨胰腺导管腺癌(PDA)微环境免疫状态与预后的关系。肿瘤浸润性淋巴细胞(TIL)密度越高，预后越好。重要的是，即使有高密度的TIL，程序性细胞死亡配体1(PD-L1)表达的PDA细胞比PD-L1表达阴性的患者预后更差。TIL密度高/PD-L1表达阴性的肿瘤微环境与较好的预后密切相关。评估肿瘤微环境中的联合免疫学状态可以预测PDA患者手术切除后的预后。
Abstract The associations of the immunological status of the pancreatic ductal adenocarcinoma (PDA) microenvironment with prognosis were assessed. A high tumor-infiltrating lymphocyte (TIL) density was associated with a better prognosis. Importantly, even with a high density of TILs, the PDA cells with programed cell death-ligand 1 (PD-L1) expression showed a worse prognosis than the patients with negative PD-L1 expression. A significant association between a better prognosis and a tumor microenvironment with a high TIL density/negative PD-L1 expression was observed. Assessments of a combined immunological status in the tumor microenvironment may predict the prognosis of PDA patients following surgical resection.