Roles of the hypocretin/orexins in the regulation of sleep and wakefulness.
Roles of the hypocretin/orexins in the regulation of sleep and wakefulness.
复制标题
DOI：
--
复制
发表时间：
2008-02
期刊：
影响因子：
--
通讯作者：
A. Terao;T. Haruyama;K. Kimura
中科院分区：
文献类型：
--
作者：
A. Terao;T. Haruyama;K. Kimura
下丘脑分泌素/食欲素仅在下丘脑背侧和外侧产生，但其投射在大脑内广泛存在并发挥重要作用。在本文中，我们回顾了下丘脑分泌素/食欲素肽的独立发现、该系统的神经解剖学以及与睡眠障碍发作性睡病的联系，从而得出该系统在睡眠和觉醒调节中发挥关键作用的观点。
Hypocretin/orexin is produced exclusively in the dorsal and lateral hypothalamus but its projection is widespread within the brain and plays important roles. In this paper, we review the independent discoveries of the hypocretin/orexin peptides, the neuroanatomy of this system, and the link to the sleep disorder narcolepsy that has led to the idea that this system plays a crucial role in the regulation of sleep and wakefulness.