Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease
Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease
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DOI：
10.2169/internalmedicine.55.6640
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发表时间：
2016-01-01
影响因子：
1.2
通讯作者：
Hiasa, Yoichi
中科院分区：
文献类型：
--
作者：
Miyake, Teruki;Matsuura, Bunzo;Hiasa, Yoichi
3，5，3 '-三碘-L-甲状腺原氨酸调节葡萄糖代谢、脂质代谢和肝脂肪变性。几个研究小组已经表明甲状腺功能减退症与非酒精性脂肪肝和甲状腺功能减退症与非酒精性脂肪性肝炎（NASH）之间的关系。然而，甲状腺功能亢进对NASH的影响尚未研究。我们在此报告甲状腺激素对NASH合并Graves病患者NASH病理状态的影响。在我们的病例中，肝酶水平随着甲状腺激素水平的增加而改善;然而，肝酶水平随着甲状腺激素水平的改善而恶化。因此，甲亢可改善NASH的病理状态。
3,5,3'-triiodo-L-thyronine regulates the glucose metabolism, lipid metabolism, and hepatic steatosis. Several groups have shown the relationships between hypothyroidism and nonalcoholic fatty liver and hypothyroidism and nonalcoholic steatohepatitis (NASH). However, the effect of hyperthyroidism on NASH has not yet been investigated. We herein report effects of thyroid hormone on the pathological condition of NASH in a patient with NASH complicated by Graves' disease. In our case, the liver enzyme level improved with the increasing thyroid hormone level; however, the liver enzyme level was aggravated with the improving thyroid hormone level. Therefore, hyperthyroidism may improve the pathological condition of NASH.